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From neuron to brain : a cellular and molecular approach to the function of the nervous system / John G. Nicholls.
By: Nicholls, John G
.
Contributor(s): Martin, A. Robert | Wallace, Bruce G | Kuffler, Stephen W.
Material type: 
BookPublisher: Sunderland, MA : Sinauer Associates, 1992Edition: 3rd ed.Description: xx, 807 p. : ill. (some col.) ; 25 cm.ISBN: 0878935800.Subject(s): Neurophysiology | Brain | NeuronsDDC classification: 573.8
Contents:
Part One: Properties of neurons and glia: Analysis of signals in the nervous system -- Membrane channels and signaling -- Ionic basis of the resting potential -- Ionic basis of the action potential -- Neurons as conductors of electricity -- Properties and functions of neuroglial cells -- Part Two: Communication between excitable cells: Principles of synaptic transmission -- Indirect mechanisms of synaptic transmission -- Cellular and molecular biochemistry of synaptic transmission -- Identification and function of transmitters in the central nervous system -- Part Three: Development and regeneration in the nervous system: Neuronal development and the formation of synaptic connections -- Denervation and regeneration of synaptic connections -- Part Four: Integrative mechanisms: Leech and aplysia: two simple nervous systems -- Transduction and processing of sensory signals -- Motor systems -- Part Five: The visual system: Retina and lateral geniculate nucleus -- The visual cortex -- Genetic and environmental influences in the mammalian visual system -- Part Six: Conclusion: Perspectives.
| Item type | Current library | Call number | Copy number | Status | Barcode | |
|---|---|---|---|---|---|---|
| General lending | MTU Bishopstown Library Lending | 573.8 (Browse shelf(Opens below)) | 1 | Available | 00070683 |
Total holds: 0
Enhanced descriptions from Syndetics:
Up-to-date third edition which presents a coherent description of the nervous system from the perspective of modern work on molecular biology, cellular and developmental biology, biophysics, neurophysiology, neurochemistry and neuroanatomy.
Rev. ed. of: From neuron to brain / Stephen W. Kuffler, John G. Nicholls, A. Robert Martin. 2nd ed. 1984.
Bibliography: (pages 729-777) and index.
Part One: Properties of neurons and glia: Analysis of signals in the nervous system -- Membrane channels and signaling -- Ionic basis of the resting potential -- Ionic basis of the action potential -- Neurons as conductors of electricity -- Properties and functions of neuroglial cells -- Part Two: Communication between excitable cells: Principles of synaptic transmission -- Indirect mechanisms of synaptic transmission -- Cellular and molecular biochemistry of synaptic transmission -- Identification and function of transmitters in the central nervous system -- Part Three: Development and regeneration in the nervous system: Neuronal development and the formation of synaptic connections -- Denervation and regeneration of synaptic connections -- Part Four: Integrative mechanisms: Leech and aplysia: two simple nervous systems -- Transduction and processing of sensory signals -- Motor systems -- Part Five: The visual system: Retina and lateral geniculate nucleus -- The visual cortex -- Genetic and environmental influences in the mammalian visual system -- Part Six: Conclusion: Perspectives.
Table of contents provided by Syndetics
- Part 1 Introduction
- Chapter 1. Principles of Signaling and Organization (p. 3)
- Signaling in Simple Neuronal Circuits (p. 4)
- Organization of the Retina (p. 5)
- Signaling in Nerve Cells (p. 9)
- Cellular and Molecular Biology of Neurons (p. 19)
- Signals for Development of the Nervous System (p. 20)
- Regeneration of the Nervous System after Injury (p. 21)
- Part 2 Signaling in the Nervous System
- Chapter 2. Ion Channels and Signaling (p. 25)
- Properties of Ion Channels (p. 26)
- Measurement of Single-Channel Currents (p. 29)
- Box 2.1 Measuring Channel Conductance (p. 37)
- Chapter 3. Structure of Ion Channels (p. 39)
- The Nicotinic Acetylcholine Receptor (p. 41)
- A Receptor Superfamily (p. 49)
- Voltage-Activated Channels (p. 50)
- Other Channels (p. 55)
- Diversity of Subunits (p. 58)
- Conclusion (p. 58)
- Box 3.1 Cloning Receptors and Channels (p. 40)
- Box 3.2 Classification of Amino Acids (p. 45)
- Box 3.3 Expression of Receptors and Channels in Xenopus Oocytes (p. 46)
- Chapter 4. Transport Across Cell Membranes (p. 61)
- The Sodium-Potassium Exchange Pump (p. 62)
- Calcium Pumps (p. 64)
- Sodium-Calcium Exchange (p. 66)
- Chloride Transport (p. 69)
- Transport of Neurotransmitters (p. 70)
- Molecular Structure of Transporters (p. 72)
- Significance of Transport Mechanisms (p. 74)
- Chapter 5. Ionic Basis of the Resting Potential (p. 77)
- A Model Cell (p. 78)
- Membrane Potentials in Squid Axons (p. 81)
- Changes in Membrane Potential (p. 88)
- Chapter 6. Ionic Basis of the Action Potential (p. 91)
- Sodium and Potassium Currents (p. 92)
- Voltage Clamp Experiments (p. 94)
- Gating Currents (p. 103)
- The Role of Calcium in Excitation (p. 110)
- Box 6.1 The Voltage Clamp (p. 95)
- Chapter 7. Neurons as Conductors of Electricity (p. 113)
- Passive Electrical Properties of Nerve and Muscle Membranes (p. 114)
- Propagation of Action Potentials (p. 121)
- Conduction in Dendrites (p. 128)
- Pathways for Current Flow between Cells (p. 128)
- Box 7.1 Electrotonic Potentials and the Membrane Time Constant (p. 120)
- Box 7.2 Classification of Nerve Fibers in Vertebrates (p. 125)
- Box 7.3 Stimulating and Recording with External Electrodes (p. 127)
- Box 7.4 Current Flow between Cells (p. 130)
- Chapter 8. Properties and Functions of Neuroglial Cells (p. 133)
- Physiological Properties of Neuroglial Cell Membranes (p. 137)
- Functions of Neuroglial Cells (p. 140)
- Effects of Neuronal Activity on Glial Cells (p. 146)
- Glial Cells and the Blood-Brain Barrier (p. 150)
- Glial Cells and Immune Responses of the CNS (p. 153)
- Box 8.1 The Blood-Brain Barrier (p. 151)
- Chapter 9. Principles of Direct Synaptic Transmission (p. 155)
- Nerve Cells and Synaptic Connections (p. 156)
- Electrical Synaptic Transmission (p. 158)
- Chemical Synaptic Transmission (p. 160)
- Box 9.1 Electrical Model of the Motor End Plate (p. 169)
- Direct Synaptic Inhibition (p. 171)
- Chapter 10. Indirect Mechanisms of Synaptic Transmission (p. 177)
- Metabotropic Receptors and G Proteins (p. 178)
- Direct Modulation of Channel Function by G Proteins (p. 180)
- G Protein Activation of Cytoplasmic Second Messenger Systems (p. 184)
- Calcium as an Intracellular Second Messenger (p. 193)
- Prolonged Time Course of Indirect Transmitter Action (p. 195)
- Box 10.1 Identifying Responses Mediated by G Proteins (p. 181)
- Box 10.2 Cyclic AMP as a Second Messenger (p. 187)
- Box 10.3 Diacylglycerol and IP[subscript 3] as Second Messengers (p. 190)
- Box 10.4 Formation and Metabolism of Arachidonic Acid (p. 192)
- Chapter 11. Transmitter Release (p. 199)
- Characteristics of Transmitter Release (p. 200)
- Quantal Release (p. 206)
- Vesicle Hypothesis of Transmitter Release (p. 213)
- Chapter 12. Synaptic Plasticity (p. 227)
- Short-Term Changes in Signaling (p. 229)
- Long-Term Changes in Signaling (p. 232)
- Chapter 13. Cellular and Molecular Biochemistry of Synaptic Transmission (p. 243)
- Neurotransmitters (p. 244)
- Neurotransmitter Synthesis (p. 247)
- Storage of Transmitters in Synaptic Vesicles (p. 254)
- Axonal Transport (p. 256)
- Transmitter Release and Vesicle Recycling (p. 258)
- Transmitter Receptor Localization (p. 264)
- Removal of Transmitters from the Synaptic Cleft (p. 265)
- Box 13.1 The SNARE Hypothesis (p. 262)
- Chapter 14. Neurotransmitters in the Central Nervous System (p. 271)
- Mapping Transmitter Distribution (p. 273)
- Peptide Transmitters in the CNS (p. 280)
- Regulation of Central Nervous System Function by Biogenic Amines (p. 282)
- Box 14.1 Molecular Methods and CNS transmitters (p. 272)
- Part 3 Integrative Mechanisms
- Chapter 15. Cellular Mechanisms of Integration and Behavior in Leeches, Ants, and Bees (p. 291)
- From Neurons to Behavior and Vice Versa (p. 292)
- Navigation by Ants and Bees (p. 304)
- Why Should One Work on Invertebrate Nervous Systems? (p. 313)
- Chapter 16. Autonomic Nervous System (p. 315)
- Functions under Involuntary Control (p. 316)
- Synaptic Transmission by Postganglionic Axons (p. 321)
- Box 16.1 The Path to Understanding Sympathetic Mechanisms (p. 323)
- Chapter 17. Transduction of Mechanical and Chemical Stimuli (p. 333)
- Stimulus Coding by Mechanoreceptors (p. 334)
- Transduction of Mechanical Stimuli (p. 340)
- Olfaction (p. 347)
- Mechanisms of Taste (Gustation) (p. 350)
- Transduction of Nociceptive and Thermal Stimuli (p. 352)
- Box 17.1 Sensory Epithelia of the Inner Ear (p. 342)
- Chapter 18. Processing of Somatosensory and Auditory Signals (p. 355)
- The Somatosensory System: Tactile Recognition (p. 356)
- The Auditory System: Encoding Sound Frequency (p. 366)
- Box 18.1 Brodmann's Areas (p. 364)
- Chapter 19. Transduction and Signaling in the Retina (p. 379)
- The Eye (p. 380)
- The Retina (p. 381)
- Visual Pigments (p. 384)
- Transduction by Photoreceptors (p. 387)
- Transmission from Photoreceptors to Bipolar Cells (p. 394)
- Receptive Fields of Ganglion Cells (p. 399)
- Box 19.1 Adaptation of Photoreceptors (p. 391)
- Chapter 20. Signaling in the Lateral Geniculate Nucleus and the Primary Visual Cortex (p. 407)
- The Lateral Geniculate Nucleus (p. 408)
- Cytoarchitecture of the Cortex (p. 411)
- Strategies for Exploring the Cortex (p. 414)
- Chapter 21. Functional Architecture of the Visual Cortex (p. 427)
- Ocular Dominance Slabs and Orientation Columns (p. 428)
- Parallel Processing of Form, Motion, and Color (p. 432)
- The Integration of Visual Information (p. 439)
- Where Do We Go from Here? (p. 442)
- Box 21.1 Color Constancy (p. 438)
- Box 21.2 Corpus Callosum (p. 444)
- Chapter 22. Cellular Mechanisms of Motor Control (p. 447)
- The Motor Unit (p. 449)
- Spinal Reflexes (p. 453)
- Generation of Coordinated Movement (p. 456)
- The Organization of Motor Pathways (p. 462)
- Motor Cortex and the Execution of Voluntary Movement (p. 464)
- The Cerebellum (p. 468)
- The Basal Ganglia (p. 473)
- Box 22.1 Extracellular Recording of Motor Activity (p. 465)
- Part 4 Development of the Nervous System
- Chapter 23. Development of the Nervous System (p. 479)
- Early Neural Morphogenesis (p. 481)
- Regional Specification of Neural Tissue (p. 485)
- Determination of Neuronal and Glial Cell Identity (p. 488)
- Axon Outgrowth (p. 497)
- Axon Guidance (p. 500)
- Target Innervation (p. 506)
- Synapse Formation (p. 506)
- Growth Factors and Survival of Neurons (p. 512)
- Competitive Interactions during Development (p. 516)
- General Considerations of Neural Specificity (p. 520)
- Box 23.1 Discovery of Nerve Growth Factor (p. 513)
- Chapter 24. Denervation and Regeneration of Synaptic Connections (p. 525)
- Changes in Axotomized Neurons and the Surrounding Glial Cells (p. 526)
- Effects of Denervation on Postsynaptic Cells (p. 528)
- Regeneration in the Vertebrate Peripheral Nervous System (p. 536)
- Role of Basal Lamina at Regenerating Neuromuscular Synapses (p. 538)
- Regeneration in the Mammalian CNS (p. 541)
- Chapter 25. Critical Periods in Visual and Auditory Systems (p. 549)
- The Visual System in Newly Born Monkeys and Kittens (p. 550)
- Effects of Abnormal Experience in Early Life (p. 555)
- Requirements for Maintenance of Functioning Connections in the Visual System (p. 560)
- Cellular and Molecular Mechanisms of Deprivation Changes (p. 563)
- Critical Periods in the Auditory System (p. 567)
- Critical Periods for Higher Functions (p. 570)
- Part 5 Conclusion
- Chapter 26. Open Questions (p. 575)
- Appendix A. Current Flow in Electrical Circuits (p. 1)
- Appendix B. Metabolic Pathways for the Synthesis and Inactivation of Low-Molecular-Weight Transmitters (p. 1)
- Appendix C. Structures and Pathways of the Brain (p. 1)
- Glossary (p. 1)
- Bibliography (p. 1)
- Index (p. 1)