Enhanced descriptions from Syndetics:

Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references.

This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry

Table of contents provided by Syndetics

• Chapter 1 Introduction
• I What is Mass Spectrometry
• II History
• III Applications
• IV The Data of Mass Spectrometry and Its Presentation
• 1 Spectra
• 2 Total Ion Current
• 3 Mass Chromatograms and Profiles
• V Definition of Terms
• 1 Mass-To-Charge Ratio (m/z)
• 2 Multiple-Charge Ions
• 3 Ions Representing an Intact Molecule
• 4 Resolution/Resolving Power
• 5 Intensity vs Abundance
• Chapter 2 The Mass Spectrometer
• I Introduction
• II Ion Guides
• III Types of m/z Analyzers
• 1 Time-Of-Flight
• A Linear.1) Resolving Power of the Linear TOF Instrument.2) Time-Lag Focusing.3) Beam Deflection
• B Reflectron
• C Orthogonal Acceleration
• D Ion Detection in the TOF Analyzer.1) Time Slice Detection.2) Time Array Detection.3) TAD with Transient Recorders.4) TAD with an Integrating Transient Recorder.5) Hadamard Transform TOF MS
• 2 Quadrupole Ion Traps
• A 3D Quadrupole Ion Traps
• B Linear Quadrupole Ion Traps
• 3 Orbitrap
• A Historical Aspects
• B Operating Principles
• 4 Transmission Quadrupoles
• A QMF Equations of Motion
• B The Stability Diagram
• C Characteristics of Output
• D Spectral Skewing
• E Performance Limitations
• 5 Sector instruments
• A Single-focusing Instruments.1) Operating Principles.2) Performance Limitations
• B Double-Focusing Instruments
• 6 FTICR-MS
• C Hardware Configuration
• D Operational Considerations
• E Representative Applications
• IV Calibration of the m/z Scale
• 1 Electron Ionizaton (GC/MS)
• 2 Chemical Ionization (GC/MS)
• 3 Electrospray and Other Atmospheric Pressure Ionization Techniques
• V Ion Detection
• 1 General Considerations
• 2 Types of Detectors
• A Faraday Cup
• B Electron Multiplier.1) Discrete-Dynode Version.2) Continuous-Dynode Version
• C Negative-Ion Detection
• D Post-Acceleration Detection and Detection of High-Mass Ions
• E Channel Electron Multiplier Array (CEMA)
• F Electro-Optical Ion Detection
• G The Daly Detector
• H Cryogenic Detectors
• VI Vacuum Systems
• 1 Introduction
• 2 Definitions
• 3 Pressure Gauges
• A Thermal-Conductivity Gauges
• B Ionization Gauges
• 4 Types of Pumps
• A Mechanical Pumps (Low Vacuum).1) Rotary Vane.2) Scroll.3) Diaphram
• B High Vacuum.1) Turbomolecular Pumps.2) Diffusion Pumps.3) Sputter-Ion Pumps.4) Cryogenic Pumps
• Chapter 3 Mass Spectrometry/Mass Spectrometry
• I Introduction
• 1 Concept and Definitions
• 2 Nomenclature
• II Ion Dissociation
• 1 Metastable Ions
• III Instrumentation for MS/MS
• 1 MS/MS in Space
• A Tandem MS/MS.1) Triple-Quadrupole Mass Spectrometer.2) BEqQ Hybrid Instrument
• B Double-Focusing Instruments
• 2 MS/MS in Time
• IV Specialized Techniques and Applications
• 1 In-Source CAD
• 2 CAD in Conjunction with Soft Ionization
• 3 Selected Reaction Monitoring
• 4 Precursor-Ion Scan
• 5 Neutral Loss (Common Loss) Scan
• 6 Ion/Molecule Reactions
• V Identification of Unknowns from CAD Data
• 1 Accurate Mass Measurements
• 2 Library Search Utilities
• A Other Databases
• B Substructure Information
• C Use of MS Interpreter
• Chapter 4 Inlet Systems
• I Introduction
• II Batch Inlets
• 1 Heated Reservoir Inlet
• 2 Direct Inlet Probe (DIP)
• A The Chromatoprobe
• 3 Direct Exposure Probe (Desorption Chemical Ionization [DCI])
• 4 Pyrolysis
• III Continuous Inlets

Reviews provided by Syndetics

CHOICE Review

With the addition of Sparkman (Univ. of the Pacific) and Watson (Michigan State Univ., East Lansing) on the author list, and more than 300 pages and thousands of references to the previous edition, this is more of a new work than a new edition (3rd ed., 1997). It weighs in as one of the largest single books (4.4 lbs.) on the topic. The authors, both experienced teachers in the field, combine their skills to produce a fairly complete primer on mass spectrometry. Although the range of font sizes and quality of figure images are bewildering and distracting at times, the book is a very useful reference, and will be a useful work for teaching mass spectrometry. Some topics, such as APCI, jet separators, and diffusion pump operation, are quickly becoming of historical interest only, and the authors probably could have pruned the text back somewhat, but in most cases, the historical perspectives that have been added are an important part of appreciating the discipline. Some topics are covered twice, but such details do not detract from the fact that, when seasoned teachers package well-tested approaches to introducing topics, readers will benefit. Such is the case here. Summing Up: Highly recommended. General readers; upper-division undergraduates through professionals; two-year technical program students. J. Allison College of New Jersey

Author notes provided by Syndetics

J. Throck Watson is professor of chemistry and biochemistry at Michigan State University. He received his B.S. in 1961from Iowa State University and his PhD in 1965 from MIT. From 1965 - 68 he was a postdoctoral Researcher at the University of Strasbourg from which he transferred in 1969 to the University of Vanderbilt's Department of Pharmacology. In 1980 he was appointed Professor of Biochemistry and Chemistry at Michigan State University as well as Director of the J.T. Watson Mass Spectrometry Facility. In 1990 he was awarded the Pittsburgh Spectroscopy Society Award. He has published over 150 scientific papers, 15 book chapters and 4 books. He currently serves on the editorial board of Mass Spectrometry Reviews and Current Analytical Chemistry. He retired from MSU in August 2006 to complete the writing of this book.

O. David Sparkman is currently an Adjunct Professor of Chemistry at the University of the Pacific in Stockton, California; a Consultant to the National Institute of Standards and Technology Mass Spectrometry Data Center. He teaches courses in mass spectrometry and analytical chemistry and manages the mass spectrometry facility. Over the past 30 years, he has developed and taught five different ACS courses in mass spectrometry; he holds positions on the Editorial Advisory Boards of the European Journal of Mass Spectrometry. He is the author of Mass Spectrometry Desk Reference. He has developed and taught 10 sessions of an interactive Web Course on Mass Spectral Interpretation over the past 4 years. David Sparkman has been a member of ASMS since 1977 and the ACS since 1967. He is a former member of the ACS Continuing Education Committee. He was the invited teacher of the Mass Spectral Interpretation course held at the 17th International Mass Spectrometry Conference held in Prague, the Czech Republic, in August of 2006.