Transfusion and transplantation science / edited by Prof Neil Avent.
Contributor(s): Avent, Neil D
.
Material type: 
BookSeries: Fundamentals of biomedical science: Publisher: Oxford : Oxford University Press, [2018]Copyright date: ©2018Edition: Second edition.Description: xiii, 350 pages : color illustrations ; 25 cm.Content type: text Media type: unmediated Carrier type: volumeISBN: 9780198735731 (paperback).Subject(s): Blood -- Transfusion | Blood -- Transfusion -- Complications | Immunology | Blood banks | Transplantation of organs, tissues, etcDDC classification: 615.39 | Item type | Current library | Call number | Status | Notes | Barcode | |
|---|---|---|---|---|---|---|
| General lending | MTU Bishopstown Library Lending | 615.39 (Browse shelf(Opens below)) | Available | CIT Module BIOL 8013 - Core reading, CIT Module BIOL 8015 - Core reading. | 00213667 | |
| General lending | MTU Bishopstown Library Lending | 615.39 (Browse shelf(Opens below)) | Available | CIT Module BIOL 8013 - Core reading, CIT Module BIOL 8015 - Core reading. | 00213668 | |
| General lending | MTU Bishopstown Library Lending | 615.39 (Browse shelf(Opens below)) | Available | CIT Module BIOL 8013 - Core reading, CIT Module BIOL 8015 - Core reading. | 00213669 | |
| General lending | MTU Bishopstown Library Lending | 615.39 (Browse shelf(Opens below)) | Available | CIT Module BIOL 8013 - Core reading, CIT Module BIOL 8015 - Core reading. | 00213670 |
Enhanced descriptions from Syndetics:
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible.The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed--from microbiology to cytopathology to transfusion science.The science of transfusion and transplantation demands a multifaceted understanding of immunology, haematology, and genetics from the biomedical scientist. Transfusion and Transplantation Science synthesizes the essential concepts of these subjects and presents them within the practical framework of the hospital banking and transplantation centre, providing you with the knowledge and skills to specialize in this discipline.
Includes bibliographical references and index.
Introduction to basic immunology and techniques -- Human blood group antigens -- Haemolytic disease of the fetus and newborn -- Clinical use of blood components -- Microbiological testing of blood donations -- Human platelet antigens (HPA) and human neutrophil antigens (HNA) and their clinical significance -- Compatibility testing and adverse effects -- Immune-mediated red cell destruction -- Human leucocyte antigens (HLA) and their clinical significance -- Haematopoietic stem cell transportation and stem cell plasticity -- Tissue banking -- Quality issues.
CIT module BIOL 8013 - Core reading.
CIT module BIOL 8015 - Core reading.
Table of contents provided by Syndetics
- 1 Introduction to Basic Immunology and Techniques (p. 1)
- Introduction (p. 1)
- 1.1 Basic immunology and techniques (p. 4)
- 1.2 Antibody structure (p. 6)
- 1.3 Antibody function (p. 8)
- 1.4 Antigen-antibody reactions (p. 9)
- 1.5 Antibody-mediated red cell destruction (p. 10)
- 1.6 In vitro detection or antigen-antibody reactions (p. 13)
- 1.7 Techniques (p. 17)
- Chapter summary (p. 18)
- 2 Human Blood Group Antigens (p. 19)
- Introduction (p. 19)
- 2.1 Human polymorphism and evolution (p. 20)
- 2.2 The erythrocyte membrane (p. 23)
- 2.3 Blood group systems dependent on carbohydrate structures (p. 27)
- 2.4 Blood group systems dependent on protein structures (p. 33)
- 2.5 Non-polymorphic erythrocyte membrane proteins (p. 57)
- 2.6 Blood group genotyping (BGG) (p. 58)
- Chapter summary (p. 60)
- Further reading (p. 61)
- 3 Haemolytic Disease of the Fetus and Newborn (p. 62)
- Introduction (p. 62)
- 3.1 Fetal alloimmunization (p. 63)
- 3.2 Clinical management-laboratory investigations (p. 69)
- 3.3 Prophylactic anti-D (p. 72)
- 3.4 Neonatal alloimmune thrombocytopaenia (NAITP) (p. 76)
- 3.5 Fetal genotyping (p. 76)
- 3.6 Clinical management-obstetrics (p. 77)
- 3.7 Concluding comments (p. 80)
- Chapter summary (p. 80)
- Further reading (p. 80)
- 4 Clinical Use of Blood Components (p. 82)
- Introduction (p. 82)
- 4.1 Structure and function of blood (p. 83)
- 4.2 Normal physiological response to anaemia and/or bleeding (p. 83)
- 4.3 Blood coagulation (p. 84)
- 4.4 Blood components available and their appropriate use (p. 86)
- 4.3 Blood products (p. 92)
- 4.6 Special requirements (p. 93)
- 4.7 Plasma fractionation (p. 93)
- 4.8 Decision making, who needs a transfusion, risks and benefits (p. 98)
- 4.9 Alternatives to donor blood (p. 100)
- 4.10 Case history examples (p. 105)
- Chapter summary (p. 106)
- Further reading (p. 107)
- 5 Microbiological Testing of Blood Donations (p. 108)
- Introduction (p. 108)
- 5.1 Requirements for microbiological testing of blood donations (p. 109)
- 5.2 The virus life cycle: basic biology (p. 110)
- 5.3 Epidemiology for hepatitis B and C and for HIV (AIDS) (p. 111)
- 5.4 Screening strategy for mandatory viral tests (p. 119)
- 5.5 Testing strategy to protect immunocompromised patients (p. 125)
- 5.6 Bacterial tests for products stored at room temperature (p. 126)
- 5.7 Emerging issues for blood safety (p. 129)
- 5.8 Insect/animal-borne pathogens (p. 130)
- 5.9 Arthropod (insect)-borne viruses, i.e. ARBO viruses (p. 132)
- 5.10 Transmissible spongiform encephalitis, prions, and variant Creutzfeldt-Jakob disease (p. 134)
- 5.11 Quality control and blood safety (p. 136)
- 5.12 Strategies for the future and conclusion (p. 138)
- Chapter summary (p. 138)
- Further reading (p. 139)
- 6 Human Platelet Antigens (HPA) and Human Neutrophil Antigens (HNA) and Their Clinical Significance (p. 141)
- Introduction (p. 142)
- 6.1 Overview of platelet and granulocyte antigens (p. 142)
- 6.2 Human platelet antigens (HPA) (p. 144)
- 6.3 Human neutrophil antigens (HNA) (p. 151)
- 6.4 Antibody detection (p. 155)
- 6.5 Clinical significance of HPA alloantibodies (p. 165)
- 6.6 Clinical significance of HNA antibodies (p. 174)
- Chapter summary (p. 178)
- Chapter summary (p. 178)
- Further reading (p. 179)
- Discussion questions (p. 180)
- 7 Compatibility Testing and Adverse Effects (p. 181)
- Introduction (p. 181)
- 7.1 Compatibility testing (serological and non-serological) (p. 182)
- 7.2 Selection of plasma products (p. 192)
- 7.3 Selection of cellular components (p. 193)
- 7.4 Visual inspection and labelling of the units (p. 194)
- 7.5 Traceability of blood components (p. 195)
- 7.6 Adverse effects of transfusion (p. 195)
- 7.7 Monitoring the patient during transfusion (p. 199)
- 7.8 Investigation of transfusion reactions (p. 200)
- 7.9 Haemovigilance in the UK (p. 203)
- Chapter summary (p. 207)
- Further reading (p. 207)
- 8 Immune-Mediated Red Cell Destruction (p. 209)
- Introduction (p. 209)
- 8.1 What is immune (antibody-mediated) red cell destruction? (p. 210)
- 8.2 Clinical significance of red cell antibodies (p. 212)
- 8.3 Haemolytic transfusion reactions (p. 215)
- 8.4 Autoimmune haemolytic anaemias (AIMA) (p. 218)
- 8.3 Heamolytic post-transplantation of bone marrow/stem cell transplant (p. 225)
- 8.6 Haemolysis post-solid organ transplant and hyperacute rejection (p. 226)
- 8.7 Haemolytic disease of the fetus and newborn (HPFN) (p. 227)
- Chapter summary (p. 227)
- Further reacting (p. 227)
- 9 Human Leucocyte Antigens (HLA) and Their Clinical Significance (p. 229)
- Introduction (p. 229)
- 9.1 A brief history of transplantation (p. 230)
- 9.2 Human leucocyte antigens (p. 231)
- 9.3 The detection and definition of human leucocyte antigens, alleles, and antibodies (p. 237)
- 9.4 Clinical significance of human leucocyte antigens in transplantation (p. 242)
- 9.5 Clinical significance of human leucocyte antigens in transfusion (p. 249)
- 9.6 Immunosuppression (p. 253)
- 9.7 Xenotransplantation (p. 255)
- Chapter summery (p. 257)
- Further reading (p. 258)
- Discussion questions (p. 258)
- 10 Haematopoietic Stem Cell Transplantation and Stem Cell Plasticity (p. 259)
- Introduction (p. 259)
- 10.1 Stem cells (p. 260)
- 10.2 The bone marrow microenvironment (p. 262)
- 10.3 Sources and collection of haematopoietic SCs (p. 263)
- 10.4 Stem cell transplantation (p. 272)
- 10.5 Novel approaches to personalized medicine and stem cell plasticity (p. 278)
- 10.6 Concluding remarks (p. 285)
- Chapter summary (p. 285)
- Further reading (p. 286)
- 11 Tissue Banking (p. 287)
- Introduction (p. 287)
- 11.1 Types of graft (p. 288)
- 11.2 Which tissues are banked and how are they used? (p. 289)
- 11.3 How are donors selected, screened, and consented? (p. 291)
- 11.4 How are tissues retrieved? (p. 294)
- 11.5 Tissue processing and preservation (p. 298)
- 11.6 Storage and distribution (p. 305)
- 11.7 The future-regenerative medicine (p. 310)
- Chapter summary (p. 312)
- Further reading (p. 313)
- 12 Quality Issues (p. 315)
- Introduction (p. 315)
- 12.1 Evolution of quality (p. 316)
- 12.2 Quality management systems (p. 318)
- 12.3 Blood safety and quality regulations (p. 322)
- 12.4 The In Vitro Diagnostic Medical Devices Directive (p. 324)
- 12.5 Clinical laboratory accreditation (p. 324)
- 12.6 The Blood Stocks Management Scheme (p. 325)
- 12.7 Other legislation and regulatory bodies (p. 326)
- 12.8 Guidelines (p. 327)
- 12.9 Haemovìgilance (p. 327)
- Chapter summary (p. 328)
- Further reading (p. 328)
- Glossary (p. 329)
- Abbreviations (p. 335)
- Index (p. 339)