Enhanced descriptions from Syndetics:

Gives full coverage of genetics, including the step-by-step problem-solving approach pioneered by the author. The book is suitable for students who have a limited background in biology and chemistry, or for briefer courses where there is little time to cover advanced topics.

Table of contents provided by Syndetics

• Preface (p. xiii)
• 1 Genetics: An Introduction (p. 1)
• The Branches of Genetics (p. 2)
• Geneticists and Genetics Research (p. 3)
• What Do Geneticists Do? (p. 3)
• What Are Basic and Applied Research? (p. 3)
• What Organisms Are Suitable for Genetic Experimentation? (p. 5)
• Cellular Reproduction in Eukaryotes: Mitosis and Meiosis (p. 8)
• Chromosome Complement of Eukaryotes (p. 8)
• Asexual and Sexual Reproduction (p. 9)
• Mitosis (p. 10)
• Meiosis (p. 15)
• 2 Mendelian Genetics (p. 25)
• Genotype and Phenotype (p. 26)
• Mendel's Experimental Design (p. 27)
• Monohybrid Crosses and Mendel's Principle of Segregation (p. 28)
• The Principle of Segregation (p. 32)
• Representing Crosses with a Branch Diagram (p. 33)
• Confirming the Principle of Segregation: The Use of Testcrosses (p. 35)
• Dihybrid Crosses and the Mendelian Principle of Independent Assortment (p. 37)
• The Principle of Independent Assortment (p. 37)
• Branch Diagram of Dihybrid Crosses (p. 39)
• Trihybrid Crosses (p. 39)
• The "Rediscovery" of Mendel's Principles (p. 40)
• Statistical Analysis of Genetic Data: The Chi-Square Test (p. 40)
• Mendelian Genetics in Humans (p. 43)
• Pedigree Analysis (p. 43)
• Examples of Human Genetic Traits (p. 44)
• 3 Chromosomal Basis of Inheritance, Sex Linkage, and Sex Determination (p. 53)
• Chromosome Theory of Inheritance (p. 54)
• Sex Chromosomes (p. 54)
• Sex Linkage (p. 56)
• Nondisjunction of X Chromosomes (p. 58)
• Sex Determination (p. 60)
• Genotypic Sex Determination Systems (p. 60)
• Environmental Sex Determination Systems (p. 66)
• Analysis of Sex-Linked Traits in Humans (p. 66)
• X-Linked Recessive Inheritance (p. 66)
• X-Linked Dominant Inheritance (p. 68)
• Y-Linked Inheritance (p. 69)
• 4 Extensions of Mendelian Genetic Analysis (p. 75)
• Multiple Alleles (p. 76)
• ABO Blood Groups (p. 77)
• Drosphila Eye Color (p. 78)
• Modifications of Dominance Relationships (p. 79)
• Incomplete Dominance (p. 79)
• Codominance (p. 79)
• Molecular Explanations of Incomplete Dominance and Codominance (p. 79)
• Gene Interactions and Modified Mendelian Ratios (p. 81)
• Gene Interactions That Produce New Phenotypes (p. 81)
• Epistasis (p. 83)
• Essential Genes and Lethal Alleles (p. 86)
• The Environment and Gene Expression (p. 88)
• Penetrance and Expressivity (p. 88)
• Effects of the Environment (p. 89)
• Nature Versus Nurture (p. 91)
• 5 Genetic Mapping in Eukaryotes (p. 98)
• Discovery of Genetic Linkage (p. 100)
• Morgan's Linkage Experiments with Drosophila (p. 100)
• Constructing Genetic Maps (p. 102)
• Detecting Linkage Through Testcrosses (p. 102)
• Gene Mapping Using Two-Point Testcrosses (p. 104)
• Generating a Genetic Map (p. 105)
• Double Crossovers (p. 106)
• Three-Point Cross (p. 108)
• Mapping Chromosomes Using Three-Point Testcrosses (p. 109)
• Mapping the Human Genome (p. 113)
• Constructing Genetic Linkage Maps (p. 114)
• Constructing Physical Maps (p. 114)
• Integrating Genetic Linkage Maps and Physical Maps (p. 116)
• Tetrad Analysis in Certain Haploid Eukaryotes (p. 116)
• Using Tetrad Analysis to Map Two Linked Genes (p. 118)
• 6 Genetic Analysis in Bacteria and Bacteriophages (p. 127)
• Genetic Analysis of Bacteria (p. 129)
• Genetic Mapping in Bacteria by Conjugation (p. 130)
• Discovery of Conjugation in E. coli (p. 130)
• The Sex Factor F (p. 131)
• High-Frequency Recombination Strains of E. coli (p. 132)
• F' Factors (p. 132)
• Using Conjugation to Map Bacterial Genes (p. 134)
• Circularity of the E. coli Map (p. 136)
• Genetic Mapping in Bacteria by Transformation (p. 137)
• Genetic Mapping in Bacteria by Transduction (p. 138)
• Bacteriophages: An Introduction (p. 138)
• Transduction Mapping of Bacterial Chromosomes (p. 140)
• Mapping Genes of Bacteriophages (p. 143)
• Fine-Structure Analysis of a Bacteriophage Gene (p. 145)
• Recombination Analysis of rII Mutants (p. 145)
• Defining Genes by Complementation (Cis-Trans) Tests (p. 148)
• 7 Chromosomal Mutations (p. 154)
• Types of Chromosomal Mutations (p. 155)
• Variations in Chromosome Structure (p. 156)
• Deletion (p. 156)
• Duplication (p. 157)
• Inversion (p. 159)
• Translocation (p. 161)
• Fragile Sites and Fragile X Syndrome (p. 164)
• Variations in Chromosome Number (p. 165)
• Changes in One or a Few Chromosomes (p. 166)
• Changes in Complete Sets of Chromosomes (p. 170)
• 8 Gene Control of Proteins (p. 179)
• Gene Control of Enzyme Structure (p. 180)
• Garrod's Hypothesis of Inborn Errors of Metabolism (p. 180)
• The One Gene-One Enzyme Hypothesis (p. 180)
• Genetically Based Enzyme Deficiencies in Humans (p. 184)
• Phenylketonuria (p. 184)
• Albinism (p. 186)
• Lesch-Nyhan Syndrome (p. 186)
• Tay-Sachs Disease (p. 187)
• Gene Control of Protein Structure (p. 187)
• Sickle-Cell Anemia (p. 187)
• Other Hemoglobin Mutants (p. 189)
• Biochemical Genetics of the Human ABO Blood Groups (p. 189)
• Cystic Fibrosis (p. 190)
• Genetic Counseling (p. 191)
• Carrier Detection (p. 192)
• Fetal Analysis (p. 192)
• 9 DNA: The Genetic Material (p. 200)
• The Genetic Material (p. 201)
• Griffith's Transformation Experiment (p. 202)
• The Nature of the Transforming Principle (p. 203)
• The Hershey and Chase Bacteriophage Experiments (p. 204)
• The Chemical Composition of DNA and RNA (p. 204)
• The DNA Double Helix (p. 208)
• Different DNA Structures (p. 211)
• 10 DNA: Organization in Chromosomes (p. 216)
• Chromosomes of Bacteria, Archaea, and Viruses (p. 217)
• Chromosomes of Bacteria and Archaea (p. 217)
• Viral Chromosomes (p. 218)
• Eukaryotic Chromosomes (p. 220)
• The Karyotype (p. 221)
• The Molecular Structure of the Eukaryotic Chromosome (p. 222)
• Centromeres and Telomeres (p. 227)
• Unique-Sequence and Repetitive-Sequence DNA in Eukaryotic Chromosomes (p. 227)
• Unique-Sequence DNA (p. 228)
• Repetitive-Sequence DNA (p. 228)
• 11 DNA Replication (p. 233)
• Semiconservative DNA Replication (p. 234)
• The Meselson-Stahl Experiment (p. 235)
• Semiconservative DNA Replication in Eukaryotes (p. 237)
• Enzymes Involved in DNA Synthesis (p. 238)
• DNA Polymerase I (p. 238)
• Roles of DNA Polymerases (p. 239)
• Molecular Model of DNA Replication (p. 241)
• Initiation of Replication (p. 241)
• Semidiscontinuous DNA Replication (p. 242)
• DNA Replication in Eukaryotes (p. 244)
• DNA Replication and the Cell Cycle (p. 244)
• Eukaryotic Replication Enzymes (p. 246)
• Replicons (p. 246)
• Origins of Replication (p. 247)
• Replicating the Ends of Chromosomes (p. 248)
• Assembly of New DNA into Nucleosomes (p. 250)
• DNA Recombination (p. 250)
• 12 Gene Expression: Transcription (p. 256)
• Gene Expression: An Overview (p. 258)
• The Transcription Process (p. 258)
• RNA Synthesis (p. 258)
• Initiation of Transcription at Promoters (p. 260)
• Elongation and Termination of an RNA Chain (p. 262)
• Transcription in Eukaryotes (p. 262)
• Eukaryotic RNA Polymerases (p. 262)
• Transcription of Protein-Coding Genes by RNA Polymerase II (p. 262)
• Eukaryotic mRNAs (p. 264)
• Transcription of Other Genes (p. 268)
• 13 Gene Expression: Translation (p. 279)
• Proteins (p. 280)
• Chemical Structure of Proteins (p. 280)
• Molecular Structure of Proteins (p. 281)
• The Nature of the Genetic Code (p. 281)
• Deciphering the Genetic Code (p. 283)
• Characteristics of the Genetic Code (p. 284)
• Translation: The Process of Protein Synthesis (p. 286)
• Charging tRNA (p. 286)
• Initiation of Translation (p. 287)
• Elongation of the Polypeptide Chain (p. 288)
• Termination of Translation (p. 290)
• Protein Sorting in the Cell (p. 292)
• 14 Cloning and Manipulation of DNA (p. 297)
• DNA Cloning (p. 299)
• Restriction Enzymes (p. 299)
• Cloning Vectors and the Cloning of DNA (p. 301)
• Recombinant DNA Libraries (p. 305)
• Genomic Libraries (p. 305)
• Chromosome Libraries (p. 306)
• cDNA Libraries (p. 306)
• Finding a Specific Clone in a Library (p. 307)
• Screening a cDNA Library (p. 307)
• Screening a Genomic Library (p. 308)
• Identifying Genes in Libraries by Complementation of Mutations (p. 309)
• Analysis of Genes and Gene Transcripts (p. 311)
• Restriction Enzyme Analysis of Cloned DNA Sequences (p. 311)
• Restriction Enzyme Analysis of Genes in the Genome (p. 313)
• Analysis of Gene Transcripts (p. 314)
• DNA Sequencing (p. 315)
• Polymerase Chain Reaction (PCR) (p. 318)
• Applications of Recombinant DNA and PCR Techniques (p. 320)
• Analysis of Biological Processes (p. 320)
• Diagnosis of Human Genetic Diseases by DNA Analysis (p. 320)
• Isolation of Human Genes (p. 321)
• The Human Genome Project (p. 324)
• DNA Typing (p. 325)
• Gene Therapy (p. 327)
• Commercial Products (p. 328)
• Genetic Engineering of Plants (p. 328)
• Ethics and Genetics (p. 329)
• 15 Regulation of Gene Expression in Bacteria and Bacteriophages (p. 334)
• The lac Operon of E. coli (p. 335)
• Lactose as a Carbon Source for E. coli (p. 336)
• Experimental Evidence for the Regulation of the lac Genes (p. 336)
• Jacob and Monod's Operon Model for the Regulation of the lac Genes (p. 339)
• Positive Control of the lac Operon (p. 343)
• The trp Operon of E. coli (p. 344)
• Gene Organization of the Tryptophan Biosynthesis Genes (p. 344)
• Regulation of the trp Operon (p. 345)
• Regulation of Gene Expression in Phage Lambda (p. 349)
• Early Transcription Events (p. 349)
• The Lysogenic Pathway (p. 349)
• The Lytic Pathway (p. 350)
• 16 Eukaryotic Gene Regulation (p. 357)
• Levels of Control of Gene Expression in Eukaryotes (p. 359)
• Transcriptional Control (p. 359)
• RNA Processing Control (p. 364)
• mRNA Translation Control (p. 366)
• mRNA Degradation Control (p. 366)
• Protein Degradation Control (p. 367)
• Gene Regulation in Development and Differentiation (p. 367)
• Constancy of DNA in the Genome During Development (p. 368)
• Differential Gene Activity Among Tissues and During Development (p. 369)
• Immunogenetics and Chromosome Rearangements During Development (p. 370)
• Genetic Regulation of Development in Drosophila (p. 374)
• Drosophila Developmental Stages (p. 374)
• Embryonic Development (p. 374)
• Imaginal Discs (p. 377)
• Homeotic Genes (p. 377)
• 17 Genetics of Cancer (p. 385)
• Relationship of the Cell Cycle to Cancer (p. 387)
• The Two-Hit Mutation Model for Cancer (p. 388)
• Genes and Cancer (p. 390)
• Oncogenes (p. 390)
• Tumor Suppressor Genes (p. 397)
• Mutator Genes (p. 401)
• The Multistep Nature of Cancer (p. 401)
• Chemicals and Radiation as Carcinogens (p. 402)
• Chemical Carcinogens (p. 403)
• Radiation (p. 403)
• 18 DNA Mutation and Repair (p. 407)
• Adaptation Versus Mutation (p. 408)
• Mutations Defined (p. 409)
• Types of Point Mutations (p. 410)
• Reverse Mutations and Suppressor Mutations (p. 412)
• Spontaneous and Induced Mutations (p. 412)
• Spontaneous Mutations (p. 412)
• Induced Mutations (p. 414)
• The Ames Test: A Screen for Potential Mutagens (p. 419)
• DNA Repair Mechanisms (p. 420)
• Direct Correction of Mutational Lesions (p. 420)
• Repair Involving Excision of Base Pairs (p. 420)
• Human Genetic Diseases Resulting from DNA Replication and Repair Errors (p. 423)
• Screening Procedures for the Isolation of Mutants (p. 425)
• Visible Mutations (p. 425)
• Nutritional Mutations (p. 425)
• Conditional Mutations (p. 425)
• Modern Molecular Screens (p. 426)
• 19 Transposable Elements (p. 433)
• Transposable Elements in Prokaryotes (p. 434)
• Insertion Sequences (p. 434)
• Transposons (p. 436)
• Transposable Elements in Eukaryotes (p. 437)
• The Ac-Ds System in Corn (p. 437)
• Ty Elements in Yeast (p. 441)
• P Elements in Drosophila (p. 442)
• Human Retrotransposons (p. 443)
• 20 Extranuclear Genetics (p. 446)
• Organization of Extranuclear Genomes (p. 448)
• Mitochondrial Genome (p. 448)
• Chloroplast Genome (p. 451)
• RNA Editing (p. 452)
• Origin of Mitochondria and Chloroplasts (p. 453)
• Rules of Extranuclear Inheritance (p. 453)
• Examples of Extranuclear Inheritance (p. 454)
• Shoot Variegation in the Four O'Clock (p. 454)
• The [poky] Mutant of Neurospora (p. 455)
• Yeast petite Mutants (p. 456)
• Extranuclear Genetics of Chlamydomonas (p. 459)
• Human Genetic Diseases and Mitochondrial DNA Defects (p. 459)
• Infectious Heredity--Killer Yeast (p. 460)
• Contrasts to Extranuclear Inheritance (p. 461)
• Maternal Effect (p. 461)
• Genomic Imprinting (p. 463)
• 21 Population Genetics (p. 468)
• Genetic Structure of Populations (p. 470)
• Genotypic Frequencies (p. 470)
• Allelic Frequencies (p. 471)
• The Hardy-Weinberg Law (p. 473)
• Assumptions of the Hardy-Weinberg Law (p. 473)
• Predictions of the Hardy-Weinberg Law (p. 474)
• Derivation of the Hardy-Weinberg Law (p. 474)
• Extensions of the Hardy-Weinberg Law to Loci with More than Two Alleles (p. 476)
• Extensions of the Hardy-Weinberg Law to Sex-Linked Alleles (p. 476)
• Testing for Hardy-Weinberg Proportions (p. 477)
• Using the Hardy-Weinberg Law to Estimate Allelic Frequencies (p. 477)
• Genetic Variation in Natural Populations (p. 477)
• Models of Genetic Variation (p. 478)
• Measuring Genetic Variation with Protein Electrophoresis (p. 478)
• Measuring Genetic Variation with RFLPs and DNA Sequencing (p. 480)
• Changes in Genetic Structure of Populations (p. 482)
• Mutation (p. 482)
• Genetic Drift (p. 484)
• Migration (p. 486)
• Natural Selection (p. 487)
• Simultaneous Effects of Mutation and Selection (p. 494)
• Nonrandom Mating (p. 494)
• Summary of the Effects of Evolutionary Processes on the Genetic Structure of a Population (p. 495)
• Changes in Allelic Frequency Within a Population (p. 495)
• Genetic Divergence Among Populations (p. 496)
• Increases and Decreases in Genetic Variation Within Populations (p. 496)
• Summary of the Effects of Evolutionary Processes on the Conservation of Genetic Resources (p. 496)
• Molecular Genetic Techniques and Evolution (p. 496)
• DNA Sequence Variation (p. 497)
• DNA Length Polymorphisms (p. 498)
• Evolution of Multigene Families Through Gene Duplication (p. 498)
• Evolution in Mitochondrial DNA Sequences (p. 499)
• Concerted Evolution (p. 500)
• Evolutionary Relationships Revealed by RNA and Nuclear DNA Sequences (p. 500)
• 22 Quantitative Genetics (p. 507)
• The Nature of Continuous Traits (p. 509)
• Why Some Traits Have Continuous Phenotypes (p. 509)
• Questions Studied in Quantitative Genetics (p. 509)
• Statistical Tools (p. 510)
• Samples and Populations (p. 510)
• Distributions (p. 510)
• The Mean (p. 512)
• The Variance and the Standard Deviation (p. 512)
• Polygenic Inheritance (p. 514)
• Inheritance of Ear Length in Corn (p. 514)
• Polygene Hypothesis for Quantitative Inheritance (p. 515)
• Determining the Number and Location of Polygenes for a Quantitative Trait (p. 516)
• Heritability (p. 517)
• Components of the Phenotypic Variance (p. 518)
• Broad-Sense and Narrow-Sense Heritability (p. 519)
• Understanding Heritability (p. 519)
• Response to Selection (p. 520)
• Glossary (p. 1)
• Suggested Reading (p. 1)
• Solutions to Selected Questions and Problems (p. 1)
• Credits (p. 1)
• Index (p. 1)