MTU Library Catalogue

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Antibiotics : actions, origins, resistance / by Christopher Walsh.

By: Walsh, Christopher.
Contributor(s): American Society for Microbiology.
Material type: materialTypeLabelBookPublisher: Washington, D.C. : ASM Press, c2003Description: x, 335 p. : ill. (some col.) ; 26 cm.ISBN: 1555812546; 9781555812546.Subject(s): Antibiotics | Drug resistance in microorganisms | Antibiotics -- pharmacology | Drug Resistance, Bacterial | Chemistry | Pharmacology | Health and WellbeingDDC classification: 615.329 WAL
Contents:
Antibiotics : initial concepts -- Introduction to major antibiotic classes and modes of action -- Antibiotics that act on cell wall biosynthesis -- Antibiotics that block bacterial protein biosynthesis -- Antibiotics that block DNA replication and repair : the Quinolones -- Other targets of antibacterial drugs -- Natural and producer immunity versus acquired resistance -- Enzymatic destruction or modification of the antibiotic by resistant bacteria -- Antibiotic resistance by efflux pumps -- Antibiotic resistance by replacement or modification of the antibiotic target -- Regulation of antibiotic biosynthesis in producer organisms -- Polyketide antibiotic biosynthesis : assembly line enzymology -- Enzymatic assembly lines for nonribosomal peptide antibiotics -- Biosynthesis of other classes of antibiotics -- New looks at targets -- New molecules -- Contexts and challenges for the use of new antibiotics.
Summary: As antibiotics become deactivated through resistance and emerging bacterial diseases Christopher Walsh offers new insights into antibiotic modification and design. He shows how antibiotics work on targets and reviews recent strategies for finding innovative antibiotics to replace the last generation.
Holdings
Item type Current library Call number Copy number Status Barcode
General lending MTU Kerry North Campus Library First Floor Main 615.329 WAL (Browse shelf(Opens below)) 1 Available 38888000407100
Total holds: 0

Enhanced descriptions from Syndetics:

A comprehensive account of the structural classes of antibiotics that have impacted human infectious disease.* Provides an introduction to antibiotics and examines how antibiotics block specific proteins acting in essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity. * Explores the development of bacterial resistance to antibiotics, including the molecular logic that microbial producers of antibiotics use for self-protection. * Addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes, and examines the prospects for broadening the base of bacterial targets and also where new antibiotics are likely to emerge, including both synthetic chemical efforts and natural products.

Formerly CIP. Uk

Includes bibliographical references (p. 297-328) and index.

Antibiotics : initial concepts -- Introduction to major antibiotic classes and modes of action -- Antibiotics that act on cell wall biosynthesis -- Antibiotics that block bacterial protein biosynthesis -- Antibiotics that block DNA replication and repair : the Quinolones -- Other targets of antibacterial drugs -- Natural and producer immunity versus acquired resistance -- Enzymatic destruction or modification of the antibiotic by resistant bacteria -- Antibiotic resistance by efflux pumps -- Antibiotic resistance by replacement or modification of the antibiotic target -- Regulation of antibiotic biosynthesis in producer organisms -- Polyketide antibiotic biosynthesis : assembly line enzymology -- Enzymatic assembly lines for nonribosomal peptide antibiotics -- Biosynthesis of other classes of antibiotics -- New looks at targets -- New molecules -- Contexts and challenges for the use of new antibiotics.

As antibiotics become deactivated through resistance and emerging bacterial diseases Christopher Walsh offers new insights into antibiotic modification and design. He shows how antibiotics work on targets and reviews recent strategies for finding innovative antibiotics to replace the last generation.

Table of contents provided by Syndetics

  • Preface (p. xi)
  • Section I Introduction to Antibiotics (p. 1)
  • Chapter 1 Antibiotics: Initial Concepts (p. 3)
  • Section II Validated Targets and Major Antibiotic Classes (p. 11)
  • Chapter 2 Introduction to Major Antibiotic Classes and Modes of Action (p. 13)
  • Chapter 3 Antibiotics That Act on Cell Wall Biosynthesis (p. 23)
  • Chapter 4 Antibiotics That Block Bacterial Protein Biosynthesis (p. 51)
  • Chapter 5 Antibiotics That Block DNA Replication and Repair: the Quinolones (p. 71)
  • Chapter 6 Other Targets of Antibacterial Drugs (p. 79)
  • Section III Antibiotic Resistance (p. 89)
  • Chapter 7 Natural and Producer Immunity versus Acquired Resistance (p. 91)
  • Chapter 8 Enzymatic Destruction or Modification of the Antibiotic by Resistant Bacteria (p. 107)
  • Chapter 9 Antibiotic Resistance by Efflux Pumps (p. 125)
  • Chapter 10 Antibiotic Resistance by Replacement or Modification of the Antibiotic Target (p. 143)
  • Section IV Antibiotic Biosynthesis (p. 157)
  • Chapter 11 Regulation of Antibiotic Biosynthesis in Producer Organisms (p. 159)
  • Chapter 12 Polyketide Antibiotic Biosynthesis: Assembly-Line Enzymology (p. 175)
  • Chapter 13 Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics (p. 195)
  • Chapter 14 Biosynthesis of Other Classes of Antibiotics (p. 221)
  • Section V New Strategies for Finding Novel Antibiotics and Extending Their Lifetimes (p. 235)
  • Chapter 15 New Looks at Targets (p. 237)
  • Chapter 16 New Molecules (p. 271)
  • Chapter 17 Contexts and Challenges for the Use of New Antibiotics (p. 285)
  • References (p. 297)
  • Index (p. 329)