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Genes V / Benjamin Lewin.

By: Lewin, Benjamin.
Material type: materialTypeLabelBookPublisher: Oxford ; New York : Oxford University Press, 1994Description: xxiv, 1272 p. : ill. (some col.) ; 29 cm. + pbk.ISBN: 0198542879.Subject(s): GeneticsDDC classification: 576.5
Contents:
Introduction: Cells as macromolecular assemblies: Cells obey the laws of physics and chemistry -- Cells are organized into compartments -- Part 1 DNA as a store of information: Genes are mutable units -- DNA is the genetic material -- The topology of nucleic acids -- Isolating the gene -- Part 2 Translation: expressing genes as proteins: The assembly line for protein synthesis -- Transfer RNA is the translational adaptor -- Ribosomes provide a translation factory -- Messenger RNA is the template -- Part 3 Constructing the cell: The apparatus for protein localization -- Receptors and signal transduction: channels and ion uptake -- Cell cycle and growth regulation -- Part 4 Control of prokaryotic gene expression: Control at initiation: RNA polymerase-promoter interactions -- A panoply of operons: the lactose paradigm and others -- Control by RNA structure: termination and antitermination -- Phage strategies: lytic cascades and lysogenic repression -- Part 5 Perpetuation of DNA: The replicon: unit of replication -- Primosomes and replisomes: the apparatus for DNA replication -- Systems that safeguard DNA -- Part 6 Organization of the eukaryotic genome: The extraordinary power of DNA technology -- Genome size and genetic content -- The eukaryotic gene: conserved exons and unique introns -- Gene numbers: repetition and redundancy -- Genomes sequestered in organelles -- Organization of simple sequence DNA -- The genome is packaged into chromosomes -- Chromosomes consist of nucleosomes -- Part 7 Eukaryotic transcription and RNA processing: Building the transcription complex: promoters, factors and RNA polymerases -- Regulation of transcription: factors that activate the basal apparatus -- The apparatus for nuclear splicing -- RNA as catalyst: changing the informational content of RNA -- Part 8 The dynamic genome: DNA in flux: Recombination of DNA -- Transposons the mobilize via DNA -- Retroviruses and retroposons -- Rearrangement and amplification in the genome -- Part 9 Genes in development: Generation of immune diversity by gene reorganization -- Gene regulation in development: gradients and cascades -- Oncogenes: gene expression and cancer.
Holdings
Item type Current library Call number Copy number Status Barcode
General lending MTU Bishopstown Library Lending 576.5 (Browse shelf(Opens below)) 1 Available 00083174
Total holds: 0

Enhanced descriptions from Syndetics:

Genes V gives an integrated account of the structure and function of genes in both prokaryotic and eukaryotic organisms. It is thoroughly up-to-date with the latest thinking and research in the field. Successive editions have provided an integrated account of the whole field of modern molecular genetics and this edition continues that approach, providing a new synthesis with a much greater emphasis on how genes function in their biological context. The book begins with an introductory overview of material that the student should have encountered in previous courses. These first two chapters consider the cell as an assembly of macromolecules, reviewing the function of these molecules and how they are organized into cell organelles. There follows a detailed examination of the role and function of DNA with increased emphasis on genetic mapping in the context of human disease. The third part of the book discusses translation and has been thoroughly updated to reflect new knowledge about structure and the specificity on DNA function. A new section on cell biology follows. This brings together much information that was scattered in previous editions of the book and integrates it with new knowledge on protein transport, signal transduction, and the cell cycle. The section on gene expression has been thoroughly modernized and updated as have the two chapters which follow, one of which gives an entirely new account of gene sizes, organization and differences in eukaryotes. The book gives, for the first time, a unifying concept for eukaryotic transcription and its regulation reflecting work done since 1990. The chapter on recombination has been entirely rewritten and is followed by updated coverage of manipulations of DNA: transposons, retroviruses, and rearrangements. The book concludes with chapters examining in detail the role of genes in some of the key areas of molecular biology research, molecular immunology, development, and oncogenesis. Changes in the content of the book, which have given it greater coherence and a much more logical structure, are reflected by a new design bringing greater clarity, there are fewer tables and those that remain have been redesigned and simplified. All figures have been redrawn in a modern style using state-of-the-art graphics in full color.

Includes bibliographical references and index.

Introduction: Cells as macromolecular assemblies: Cells obey the laws of physics and chemistry -- Cells are organized into compartments -- Part 1 DNA as a store of information: Genes are mutable units -- DNA is the genetic material -- The topology of nucleic acids -- Isolating the gene -- Part 2 Translation: expressing genes as proteins: The assembly line for protein synthesis -- Transfer RNA is the translational adaptor -- Ribosomes provide a translation factory -- Messenger RNA is the template -- Part 3 Constructing the cell: The apparatus for protein localization -- Receptors and signal transduction: channels and ion uptake -- Cell cycle and growth regulation -- Part 4 Control of prokaryotic gene expression: Control at initiation: RNA polymerase-promoter interactions -- A panoply of operons: the lactose paradigm and others -- Control by RNA structure: termination and antitermination -- Phage strategies: lytic cascades and lysogenic repression -- Part 5 Perpetuation of DNA: The replicon: unit of replication -- Primosomes and replisomes: the apparatus for DNA replication -- Systems that safeguard DNA -- Part 6 Organization of the eukaryotic genome: The extraordinary power of DNA technology -- Genome size and genetic content -- The eukaryotic gene: conserved exons and unique introns -- Gene numbers: repetition and redundancy -- Genomes sequestered in organelles -- Organization of simple sequence DNA -- The genome is packaged into chromosomes -- Chromosomes consist of nucleosomes -- Part 7 Eukaryotic transcription and RNA processing: Building the transcription complex: promoters, factors and RNA polymerases -- Regulation of transcription: factors that activate the basal apparatus -- The apparatus for nuclear splicing -- RNA as catalyst: changing the informational content of RNA -- Part 8 The dynamic genome: DNA in flux: Recombination of DNA -- Transposons the mobilize via DNA -- Retroviruses and retroposons -- Rearrangement and amplification in the genome -- Part 9 Genes in development: Generation of immune diversity by gene reorganization -- Gene regulation in development: gradients and cascades -- Oncogenes: gene expression and cancer.

Table of contents provided by Syndetics

  • Introduction
  • Cells as Macromolecular Assemblies
  • 1 Cells Obey the Laws of Physics and Chemistry
  • 2 Cells Are Organized Into Compartments
  • Part 1 DNA as a Store of Information
  • 3 Genes Are Mutable Units
  • 4 DNA Is the Genetic Material
  • 5 The Topology of Nucleic Acids
  • 6 Isolating the Gene
  • Part 2 Translation: Expressing Genes as Proteins
  • 7 The Assembly Line for Protein Synthesis
  • 8 Transfer RNA Is the Translational Adapter
  • 9 Ribosomes Provide a Translation factory
  • 10 Messenger RNA Is the Template
  • Part 3 Constructing the Cell
  • 11 The Apparatus for Protein Localization
  • 12 Receptors and Signal Transduction: Channels and Ion Uptake
  • 13 Cell Cycle and Growth Regulation
  • Part 4 Control of Prokaryotic Gene Expression
  • 14 Control at Initiation: RNA Polymerase-Promoter Interactions
  • 15 A Panoply of Operons: the Lactose Paradigm and Others
  • 16 Control by RNA Structure: Termination and Antitermination
  • 17 Phage Strategies: Lytic Cascades and Lysogenic Repression
  • Part 5 Perpetuation of DNA
  • 18 The Replicon: Unit of Replication
  • 19 Primosomes and Replisomes: the Apparatus for DNA Replication
  • 20 Systems that Safeguard DNA
  • Part 6 Organization of yhe Eukaryotic Gene
  • 21 The Extraordinary Power of DNA Technology
  • 22 Genome Size and Genetic Content
  • 23 The Eukaryotic Gene: Conserved Exons and Unique Introns
  • 24 Gene Numbers: Repetition and Redundancy
  • 25 Genomes Sequestered in Organelles
  • 26 Organization of Simple Sequence DNA
  • 27 The Genome is Packaged into Chromosomes
  • 28 Chromosomes Consist of Nucleosomes
  • Part 7 Eukaryotic Transcription and RNA Processing
  • 29 Building the Transcription Complex: Promoters, Factors, and RNA Polymerases
  • 30 Regulation of Transcription: Factors that Activate the Basal Apparatus
  • 31 The Apparatus for Nuclear Splicing
  • 32 RNA as Catalyst: Changing the Informational Content of RNA
  • Part 8 The Dynamic Genome: DNA un Flux
  • 33 Recombination of DNA
  • 34 Transposons that Mobilize via DNA
  • 35 Retroviruses and Retroposons
  • 36 Rearrangement and Amplification in the Genome
  • Part 9 Genes In Development
  • 37 Generation of Immune Diversity by Gene Reorganization
  • 38 Gene Regulation in Development: Gradients and Cascades
  • 39 Oncogenes: Genes Expression and Cancer
  • Epilogue
  • Landmark Shifts in Perspective
  • Glossary
  • Index

Reviews provided by Syndetics

CHOICE Review

This edition continues to build on the excellent tradition of its predecessors (Genes IV, CH, Oct'90; Genes: 3rd ed., CH, Sep'87; 2nd ed., 1985; 1st ed., CH, Oct'83). Lewin has assembled an easy-to-understand and highly readable account of molecular biology augmented with clearly rendered illustrations and graphics. However, this reviewer believes that the book falls short of one of the author's goals--to serve as an introductory work. Although the writing style is precise, the amount of material and detail of presentation are too broad and frequently require the reader to have a basic understanding of scientific concepts to fully utilize the knowledge presented. More comprehensive discussions of topics such as posttranslational events, protein-DNA interactions and control of bacterial gene expression, eukaryotic gene expression, and eukaryotic transcription and RNA processing are included in this edition. Each chapter ends with a brief summary and a short bibliography that categorizes references for the reader as reviews or discoveries. Lewin's book is required reading for anyone who wants an excellent, comprehensive review of molecular biology. Upper-division undergraduate through faculty. J. R. Palisano; University of the South

Author notes provided by Syndetics

Benjamin Lewin took his undergraduate and postgraduate degrees from Cambridge (England). He was then editor of Nature New Biology and a visiting fellow at the National Institutes for Health. He has been editor of Cell, the premier journal in the field, since 1974. He has unique access to the very best of current research results and thinking.