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Foye's principles of medicinal chemistry / David A. Williams and Thomas L. Lemke.

By: Williams, David A, 1938-.
Contributor(s): Lemke, Thomas L.
Material type: materialTypeLabelBookPublisher: Philadelphia : Lippincott Williams & Wilkins, 2002Edition: 5th ed.Description: xii, 1114 p. : ill. ; 29 cm. + hbk.ISBN: 0683307371; 9780683307375.Other title: Principles of medicinal chemistry.Subject(s): Pharmaceutical chemistry | Health and WellbeingDDC classification: 616.0756 | 615.19 WIL
Contents:
Introduction: Origins of medicinal chemistry / William O. Foye -- Part I Principles of drug discovery -- Overview: Drug design and development: a perspective / Michael Williams -- Natural products / Alice M. Clark -- Drug design and relationship of functional groups to pharmacologic activity / James J. Knittel and Robin M. Zavod -- Molecular modeling and drug design / Eric Billings --Receptors and drug action / Timothy J. Maher and David A. Johnson -- Drug design through enzyme inhibition / Stephen G. Kerr -- Peptide and protein drugs / Michael Mokotoff -- Physicochemical and biopharmaceutical properties of drug substances and pharmacokinetics / Sunil Jambhekar -- Drug metabolism / David A. Williams -- U.S. drug regulation: an overview / Douglas J. Pisano -- Part II Pharmacodynamic agents -- Overview: Drug receptors: a perspective / David J. Triggle -- Section 1 Drugs affecting neurotransmission: Drugs affecting cholinergic neurotransmission / Danny L. Lattin and E. Kim Fifer -- Drugs affecting adrenergic neurotransmission / Robert Griffith -- Serotonin receptors and drugs affecting serotonergic neurotransmission / Richard A. Glennon and Malgorzata Dukat -- Local Anesthetics / Matthias C. Lu -- Section 2 Drugs affecting central nervous system: Volatile anesthetics / Timothy J. Maher -- Hypnotics / William Soine -- Antiseizure drugs / Barbara W. Leduc -- Psychotherapeutic drugs: antipsychotic and anxiolytic agents / Raymond G. Booth and John L. Neumeyer -- Hallucinogens, stimulants, and related drugs of abuse / Richard A. Glennon -- Opioid analgesics / David S. Fries -- Drugs used to treat neuromuscular disorders: antiparkinsonian and spasmolytic agents / Raymond G. Booth and John L. Neumeyer -- Section 3 Drugs affecting the cardiovascular system: Cardiac agents: cardiac glycosides, antianginal, and antiarrhythmic drugs / Ahmed S. Mehanna -- Diuretics / Gary O. Rankin -- Angiotensin converting enzyme inhibitors, antagonists and calcium blockers / Marc W. Harrold -- Central and peripheral sympatholytics and vasodilators / David A. Williams -- Antihyperlipoproteinemics and inhibitors of cholesterol biosynthesis / Marc W. Harrold -- Antithrombotics, thrombolytics, coagulants and plasma extenders / Robert B. Palmer -- Section 4 Drugs affecting the hormonal systems: Insulin and oral hypoglycemic drugs / Robert A. Wiley --Adrenocorticoids / Duane D. Miller, Robert W. Brueggemeier and James T. Dalton -- Estrogen, Progestins and Androgens / Robert W. Brueggemeier, Duane D. Miller and James T. Dalton -- Thyroid Function and Thyroid Drugs / Ali R. Banijamali -- Calcium Homeostasis / Robin M. Zavod -- Section 5 Drugs affecting the immune systems: Nonsteroidal anti-inflammatory agents / Ronald F. Borne -- Antihistamines and related antiallergic and antiulcer agents / Wendel L. Nelson -- Section 6 Chemotherapeutic agents: Antibiotics and antimicrobial agents / Lester A. Mitscher -- Antiparasitic agents / Thomas L. Lemke --Antifungal drugs / Robert Griffith and Timothy Tracy -- Antimycobacterial agents / Thomas L. Lemke -- Cancer and Cancer Chemotherapy / Patrick S. Callery and Peter M. Gannett -- Antiviral agents and Protease inhibitors / Manohar L. Sethi -- Part III Recent advances in drug discovery -- Pharmaceutical biotechnology / Robert D. Sindelar -- Gene Therapy / Ronald E. Reid -- Antisense therapeutic agents / Marilyn K. Speedie -- Selective estrogen receptor modulators / V. Craig Jordan.
Holdings
Item type Current library Call number Copy number Status Barcode
General lending MTU Bishopstown Library Lending 616.0756 (Browse shelf(Opens below)) 1 Available 00079003
General lending MTU Kerry North Campus Library First Floor Main 615.19 WIL (Browse shelf(Opens below)) 1 Available 38888000571558
Total holds: 0

Enhanced descriptions from Syndetics:

This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.

Principles of medicinal chemistry.

Includes bibliographical references and indexes.

Introduction: Origins of medicinal chemistry / William O. Foye -- Part I Principles of drug discovery -- Overview: Drug design and development: a perspective / Michael Williams -- Natural products / Alice M. Clark -- Drug design and relationship of functional groups to pharmacologic activity / James J. Knittel and Robin M. Zavod -- Molecular modeling and drug design / Eric Billings --Receptors and drug action / Timothy J. Maher and David A. Johnson -- Drug design through enzyme inhibition / Stephen G. Kerr -- Peptide and protein drugs / Michael Mokotoff -- Physicochemical and biopharmaceutical properties of drug substances and pharmacokinetics / Sunil Jambhekar -- Drug metabolism / David A. Williams -- U.S. drug regulation: an overview / Douglas J. Pisano -- Part II Pharmacodynamic agents -- Overview: Drug receptors: a perspective / David J. Triggle -- Section 1 Drugs affecting neurotransmission: Drugs affecting cholinergic neurotransmission / Danny L. Lattin and E. Kim Fifer -- Drugs affecting adrenergic neurotransmission / Robert Griffith -- Serotonin receptors and drugs affecting serotonergic neurotransmission / Richard A. Glennon and Malgorzata Dukat -- Local Anesthetics / Matthias C. Lu -- Section 2 Drugs affecting central nervous system: Volatile anesthetics / Timothy J. Maher -- Hypnotics / William Soine -- Antiseizure drugs / Barbara W. Leduc -- Psychotherapeutic drugs: antipsychotic and anxiolytic agents / Raymond G. Booth and John L. Neumeyer -- Hallucinogens, stimulants, and related drugs of abuse / Richard A. Glennon -- Opioid analgesics / David S. Fries -- Drugs used to treat neuromuscular disorders: antiparkinsonian and spasmolytic agents / Raymond G. Booth and John L. Neumeyer -- Section 3 Drugs affecting the cardiovascular system: Cardiac agents: cardiac glycosides, antianginal, and antiarrhythmic drugs / Ahmed S. Mehanna -- Diuretics / Gary O. Rankin -- Angiotensin converting enzyme inhibitors, antagonists and calcium blockers / Marc W. Harrold -- Central and peripheral sympatholytics and vasodilators / David A. Williams -- Antihyperlipoproteinemics and inhibitors of cholesterol biosynthesis / Marc W. Harrold -- Antithrombotics, thrombolytics, coagulants and plasma extenders / Robert B. Palmer -- Section 4 Drugs affecting the hormonal systems: Insulin and oral hypoglycemic drugs / Robert A. Wiley --Adrenocorticoids / Duane D. Miller, Robert W. Brueggemeier and James T. Dalton -- Estrogen, Progestins and Androgens / Robert W. Brueggemeier, Duane D. Miller and James T. Dalton -- Thyroid Function and Thyroid Drugs / Ali R. Banijamali -- Calcium Homeostasis / Robin M. Zavod -- Section 5 Drugs affecting the immune systems: Nonsteroidal anti-inflammatory agents / Ronald F. Borne -- Antihistamines and related antiallergic and antiulcer agents / Wendel L. Nelson -- Section 6 Chemotherapeutic agents: Antibiotics and antimicrobial agents / Lester A. Mitscher -- Antiparasitic agents / Thomas L. Lemke --Antifungal drugs / Robert Griffith and Timothy Tracy -- Antimycobacterial agents / Thomas L. Lemke -- Cancer and Cancer Chemotherapy / Patrick S. Callery and Peter M. Gannett -- Antiviral agents and Protease inhibitors / Manohar L. Sethi -- Part III Recent advances in drug discovery -- Pharmaceutical biotechnology / Robert D. Sindelar -- Gene Therapy / Ronald E. Reid -- Antisense therapeutic agents / Marilyn K. Speedie -- Selective estrogen receptor modulators / V. Craig Jordan.

Table of contents provided by Syndetics

  • 1. Introduction and History (p. 1)
  • 2. Medicinals of Plant Origin: Historical Aspects (p. 7)
  • 3. Biopharmaceutical Properties of Drug Substances (p. 12)
  • 4. Structural Features and Pharmacologic Activity (p. 25)
  • 5. Theoretic Aspects of Drug Design (p. 50)
  • 6. Molecular Modeling (p. 58)
  • 7. Receptors and Drug Action (p. 75)
  • 8. Drug Metabolism (p. 83)
  • 9. Volatile Anesthetics (p. 141)
  • 10. Central Nervous System Depressants: Sedative-Hypnotics (p. 154)
  • 11. Anticonvulsants (p. 182)
  • 12. Neuroleptics and Anxiolytic Agents (p. 199)
  • 13. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonism Agents and Skeletal Muscle Relaxants (p. 232)
  • 14. Analgesics (p. 247)
  • 15. Central Nervous System Stimulants (p. 270)
  • 16. Local Anesthetics (p. 305)
  • 17. Cholinergic Agonists, Acetylcholinesterase Inhibitors, and Cholinergic Antagonists (p. 321)
  • 18. Adrenergic Drugs (p. 345)
  • 19. Cardic Agents: Cardiac Glycosides, Antianginals, and Antiarrhythmic Drugs (p. 366)
  • 20. Anticoagulants, Coagulants, and Plasma Extenders (p. 388)
  • 21. Diuretics (p. 405)
  • 22. Antiallergic and Antiulcer Drugs (p. 416)
  • 23. Cholesterol, Adrenocorticoids, and Sex Hormones (p. 444)
  • 24. Antilipidemic Drugs (p. 499)
  • 25. Nonsteroidal Anti-inflammatory Drugs (p. 535)
  • 26. Drugs Affecting Sugar Metabolism (p. 581)
  • 27. Amino Acids, Peptides, and Proteins (p. 601)
  • 28. Pharmaceutical Biotechnology (p. 622)
  • 29. Vitamins and Coenzymes (p. 652)
  • 30. Thyroid Function and Thyroid Drugs (p. 688)
  • 31. Metabolite Antagonism (p. 705)
  • 32. Parasite Chemotherapy (p. 730)
  • 33. Antimycobacterial Agents (p. 747)
  • 34. Antibiotics and Antimicrobial Agents (p. 759)
  • 35. Antifungal Agents (p. 803)
  • 36. Antiseptics and Disinfectants (p. 812)
  • 37. Cancer Chemotherapy (p. 822)
  • 38. Antiviral Agents (p. 846)
  • 39. Approaches to Anti-AIDS Agents (p. 862)
  • 40. Hormone Antagonists (p. 877)
  • 41. Photochemotherapy (p. 893)
  • 42. Pesticides (p. 908)
  • 43. Agents for Organ Imaging (p. 927)
  • Appendix (p. 948)
  • pK[subscript a] Values for Some Drugs and Miscellaneous Organic Acids and Bases
  • pH Values for Tissue Fluids
  • Index (p. 963)