Enhanced descriptions from Syndetics:

This text combines the basic principles and theories of transport in biological systems with fundamental bioengineering. It contains real world applications in drug delivery systems, tissue engineering, and artificial organs. Considerable significance is placed on developing a quantitative understanding of the underlying physical, chemical, and biological phenomena. Therefore, many mathematical methods are developed using compartmental approaches. The book is replete with examples and problems.

Table of contents provided by Syndetics

• Preface (p. xiii)
• Acknowledgments (p. xv)
• 1 Physical Properties of the Body Fluids and the Cell Membrane (p. 1)
• 1.1 Body Fluids (p. 1)
• 1.2 Fluid Compositions (p. 2)
• 1.3 Capillary Plasma Protein Retention (p. 3)
• 1.4 Osmotic Pressure (p. 5)
• 1.5 The Thermodynamics of Osmosis (p. 6)
• 1.6 Osmolarity (p. 7)
• 1.7 Other Factors that May Affect the Osmotic Pressure (p. 8)
• 1.8 Formation of the Interstitial Fluid (p. 8)
• 1.9 Net Capillary Filtration Rate (p. 9)
• 1.10 Lymphatic System (p. 11)
• 1.11 Solute Transport across the Capillary Endothelium (p. 12)
• 1.12 The Cell Membrane (p. 13)
• 1.13 Ion Pumps (p. 18)
• Problems (p. 20)
• 2 Solute Transport in Biological Systems (p. 23)
• 2.1 Description of Solute Transport in Biological Systems (p. 23)
• 2.2 Capillary Properties (p. 23)
• 2.3 Capillary Flow Rates (p. 24)
• 2.4 Solute Transport by Capillary Filtration (p. 25)
• 2.5 Solute Diffusion (p. 27)
• 2.6 Solute Diffusion Within Heterogeneous Media (p. 28)
• 2.7 Solute Permeability (p. 32)
• 2.8 The Irreversible Thermodynamics of Membrane Transport (p. 34)
• 2.9 Finding L[subscript p], P[subscript m], and [sigma] (p. 36)
• 2.10 Multicomponent Membrane Transport (p. 37)
• 2.11 Transport of Solutes Across the Capillary Wall (p. 38)
• 2.12 Transport of a Solute between a Capillary and the Surrounding Tissue Space (p. 43)
• 2.12.1 Shell Balances (p. 43)
• 2.12.2 The Krogh Tissue Cylinder (p. 44)
• 2.12.3 A Comparison of Convection and Diffusion Effects (p. 53)
• 2.13 Solute Transport in a Vascular Bed (p. 54)
• Problems (p. 56)
• 3 The Physical and Flow Properties of Blood (p. 61)
• 3.1 Physical Properties of Blood (p. 61)
• 3.2 Cellular Components (p. 61)
• 3.3 Rheology (p. 63)
• 3.4 Relationship Between Shear Stress and Shear Rate (p. 66)
• 3.5 The Hagan-Poiseuille Equation (p. 67)
• 3.6 Other Useful Flow Relationships (p. 68)
• 3.7 Rheology of Blood (p. 69)
• 3.8 The Casson Equation (p. 71)
• 3.9 Using the Casson Equation (p. 71)
• 3.10 The Velocity Profile for Tube Flow of a Casson Fluid (p. 73)
• 3.11 Tube Flow of Blood at Low Shear Rates (p. 74)
• 3.12 The Effect of the Diameter at High Shear Rates (p. 74)
• 3.13 Marginal Zone Theory (p. 76)
• 3.14 Using the Marginal Zone Theory (p. 79)
• 3.15 Generalized Mechanical Energy Balance Equation (p. 81)
• Problems (p. 84)
• 4 Oxygen Transport in Biological Systems (p. 87)
• 4.1 The Diffusion of Oxygen in Multicellular Systems (p. 87)
• 4.2 Hemoglobin (p. 88)
• 4.3 The Hemoglobin Oxygen-Dissociation Curve (p. 89)
• 4.4 Oxygen Levels in Blood (p. 89)
• 4.5 The Hill Equation (p. 91)
• 4.6 Other Factors that Can Affect the Oxygen-Dissociation Curve (p. 93)
• 4.7 Tissue Oxygenation (p. 94)
• 4.8 Oxygen Transport in a Bioartificial Organ (p. 98)
• 4.9 Oxygen Transport in the Krogh Tissue Cylinder (p. 101)
• 4.10 An Approximate Solution for Oxygen Transport in the Krogh Tissue Cylinder (p. 104)
• 4.11 Artificial Blood (p. 111)
• Problems (p. 113)
• 5 Pharmacokinetic Analysis (p. 115)
• 5.1 Terminology (p. 115)
• 5.2 Entry Routes for Drugs (p. 115)
• 5.3 Modeling Approaches (p. 117)
• 5.4 Factors that Affect Drug Distribution (p. 118)
• 5.4.1 Drug Distribution Volumes (p. 118)
• 5.4.2 Drug Metabolism (p. 120)
• 5.4.3 Renal Excretion of the Drug (p. 121)
• 5.5 Drug Clearance (p. 123)
• 5.5.1 Renal Clearance (p. 123)
• 5.5.2 Plasma Clearance (p. 124)
• 5.5.3 Biological Half-Life (p. 124)
• 5.6 A Model for Intravenous Injection of a Drug (p. 125)
• 5.7 Accumulation of a Drug in the Urine (p. 125)
• 5.8 Constant Infusion of a Drug (p. 126)
• 5.9 First-Order Drug Absorption and Elimination (p. 129)
• 5.10 Two-Compartment Models (p. 134)
• 5.10.1 A Two-Compartment Model for an Intravenous Injection (p. 135)
• 5.10.2 A Two-Compartment Model for First-Order Absorption (p. 138)
• Problems (p. 144)
• 6 Extracorporeal Devices (p. 147)
• 6.1 Applications (p. 147)
• 6.2 Contacting Schemes (p. 148)
• 6.3 Membrane Solute Transport (p. 148)
• 6.4 Estimating the Mass-Transfer Coefficients (p. 151)
• 6.5 Estimating the Solute Diffusivity in Blood (p. 151)
• 6.6 Hemodialysis (p. 154)
• 6.6.1 Background (p. 154)
• 6.6.2 Dialysate Composition (p. 155)
• 6.6.3 Role of Ultrafiltration (p. 155)
• 6.6.4 Clearance and Dialysance (p. 157)
• 6.6.5 Solute Transfer (p. 158)
• 6.6.6 A Single-Compartment Model of Urea Dialysis (p. 162)
• 6.6.7 Peritoneal Dialysis (p. 163)
• 6.7 Blood Oxygenators (p. 167)
• 6.7.1 Background (p. 167)
• 6.7.2 Operating Characteristics (p. 167)
• 6.7.3 Types of Oxygenators (p. 168)
• 6.7.4 Analysis of a Membrane Oxygenator, Oxygen Transfer (p. 170)
• 6.7.5 Analysis of a Membrane Oxygenator, Carbon Dioxide Transfer (p. 172)
• 6.7.6 Example Calculations for Membrane Oxygenators (p. 174)
• 6.8 Immobilized Enzyme Reactors (p. 181)
• 6.8.1 Background (p. 181)
• 6.8.2 Examples of Medical Applications of Immobilized Enzymes (p. 181)
• 6.8.3 Enzyme Reaction Kinetics (p. 183)
• 6.8.4 Reaction and Diffusion in Immobilized Enzyme Systems (p. 186)
• 6.8.5 Solving the Immobilized Enzyme Reaction-Diffusion Model (p. 188)
• 6.8.6 Special Case of a First-Order Reaction (p. 190)
• 6.8.7 Observed Reaction Rate (p. 190)
• 6.8.8 External Mass-Transfer Resistance (p. 190)
• 6.8.9 Reactor Design Equations (p. 191)
• 6.8.9.1 Packed-Bed Reactor (p. 191)
• 6.8.9.2 Well-Mixed Reactor (p. 192)
• Problems (p. 197)
• 7 Tissue Engineering (p. 201)
• 7.1 Introduction (p. 201)
• 7.2 Cell Transplantation (p. 202)
• 7.3 The Extracellular Matrix (p. 204)
• 7.3.1 Glycosaminoglycans (p. 205)
• 7.3.2 Collagens (p. 206)
• 7.3.3 Elastin (p. 206)
• 7.3.4 Fibronectin (p. 206)
• 7.3.5 Basement Membrane (p. 207)
• 7.4 Cellular Interactions (p. 207)
• 7.4.1 Cadherins (p. 208)
• 7.4.2 Selectins (p. 208)
• 7.4.3 Cell Adhesion Molecules (p. 208)
• 7.4.4 Integrins (p. 209)
• 7.4.5 Cytokines and Growth Factors (p. 209)
• 7.5 Polymeric Support Structures (p. 211)
• 7.6 Initial Response to an Implant (p. 215)
• 7.7 Tissue Ingrowth in Porous Polymeric Structures (p. 216)
• 7.8 Capillary Volume Fractions (p. 220)
• 7.9 Measuring the Blood Flow within Polymeric Support Structures (p. 220)
• 7.10 Measuring Mass-Transfer Rates (p. 222)
• 7.11 Pharmacokinetic Modeling of Inulin Transport in a Polymeric Support Structure (p. 225)
• 7.12 Cell Transplantation into Polymeric Support Structures (p. 232)
• Problems (p. 234)
• 8 Bioartificial Organs (p. 237)
• 8.1 Background (p. 237)
• 8.2 Some Immunology (p. 238)
• 8.2.1 B Lymphocytes (p. 238)
• 8.2.2 Antibodies (p. 239)
• 8.2.3 T Lymphocytes (p. 241)
• 8.2.4 Interaction between APCs, B Cells, and T Cells (p. 242)
• 8.2.5 The Immune System and Transplanted Cells (p. 244)
• 8.3 Immunoisolation (p. 244)
• 8.4 Permeability of Immunoisolation Membranes (p. 247)
• 8.5 Membrane Sherwood Number (p. 251)
• 8.6 Bioartificial Organs (p. 252)
• 8.6.1 The Bioartificial Pancreas (p. 252)
• 8.6.1.1 Bioartificial Pancreas Approaches (p. 254)
• 8.6.1.2 Intravascular Devices (p. 254)
• 8.6.1.3 Microencapsulation (p. 257)
• 8.6.1.4 Macroencapsulation (p. 259)
• 8.6.1.5 Organoid (p. 261)
• 8.7 Number of Islets Needed (p. 262)
• 8.8 Islet Insulin Release Model (p. 262)
• 8.9 Pharmacokinetic Modeling of Glucose and Insulin Interactions (p. 267)
• 8.10 Using the Pharmacokinetic Model to Evaluate the Performance of a Bioartificial Pancreas (p. 270)
• 8.11 The Bioartificial Liver (p. 275)
• 8.11.1 Artificial Liver Systems (p. 276)
• 8.11.2 Bioartificial Livers (p. 277)
• 8.11.3 Three Extracorporeal Bioartificial Livers (p. 278)
• 8.12 The Bioartificial Kidney (p. 282)
• 8.12.1 Two Configurations for a Bioartificial Kidney (p. 284)
• Problems (p. 286)
• References (p. 289)
• Suggested Readings (p. 301)
• Index (p. 305)

Author notes provided by Syndetics