MTU Library Catalogue

Syndetics cover image
Image from Syndetics

Introduction to toxicology / John Timbrell.

By: Timbrell, John A [author].
Material type: materialTypeLabelBookPublisher: London ; New York : Taylor & Francis, 2002Publisher: ©2002 Edition: Third edition.Description: ix, 215 pages : illustrations ; 25 cm.Content type: text Media type: unmediated Carrier type: volumeISBN: 0415247632 (paperback).Subject(s): ToxicologyAdditional physical formats: Electronic version: Introduction to toxicologyDDC classification: 615.9 Also available in electronic form.
Contents:
Introduction -- Disposition of toxic compounds -- Metabolism of foreign compounds -- Types of exposure and response -- Drugs as toxic substances -- Industrial toxicology -- Food additives and contaminants -- Presticides -- Environmental pollutants -- Natural products -- Household products -- Toxicity testing and risk assessment.
Holdings
Item type Current library Call number Copy number Status Barcode
General lending MTU Bishopstown Library Lending 615.9 (Browse shelf(Opens below)) 1 Available 00112721
General lending MTU Bishopstown Library Lending 615.9 (Browse shelf(Opens below)) 1 Available 00112722
Total holds: 0

Enhanced descriptions from Syndetics:

Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing.

This third edition caters for this need in a clear and easy-to-read style, featuring:
* Up-to-the-minute information
* Relevant toxicological examples that reinforce principles
* End-of-chapter essay questions
* New and redrawn illustrations
* Glossary of terms
* Extensively revised bibliography

The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.

Includes bibliographical references and index.

Introduction -- Disposition of toxic compounds -- Metabolism of foreign compounds -- Types of exposure and response -- Drugs as toxic substances -- Industrial toxicology -- Food additives and contaminants -- Presticides -- Environmental pollutants -- Natural products -- Household products -- Toxicity testing and risk assessment.

CIT Module BIOL 8007 - Core reading.

CIT Module BIOL 8009 - Core reading.

CIT Module CHEM 7003 - Core reading.

Also available in electronic form.

Table of contents provided by Syndetics

  • Preface to the First Edition (p. xi)
  • Preface to the Third Edition (p. xii)
  • Chapter 1 Introduction (p. 1)
  • Chapter outline (p. 1)
  • Historical aspects (p. 2)
  • Types of toxic substance (p. 5)
  • Types of exposure (p. 8)
  • Dose-response relationship (p. 9)
  • Summary and learning objectives (p. 15)
  • Questions (p. 16)
  • Bibliography (p. 17)
  • Chapter 2 Disposition of Toxic compounds (p. 19)
  • Chapter outline (p. 19)
  • Absorption of toxic compounds (p. 20)
  • Distribution of toxic compounds (p. 27)
  • Excretion of toxic compounds (p. 30)
  • Summary and learning objectives (p. 34)
  • Questions (p. 35)
  • Bibliography (p. 37)
  • Chapter 3 Metabolism of Foreign Compounds (p. 39)
  • Chapter outline (p. 39)
  • Introduction (p. 39)
  • Factors affecting toxic responses (p. 48)
  • Summary and learning objectives (p. 52)
  • Questions (p. 53)
  • Bibliography (p. 54)
  • Chapter 4 Types of Exposure and Response (p. 57)
  • Chapter outline (p. 57)
  • Types of exposure (p. 57)
  • Route of exposure (p. 58)
  • Types of toxic response (p. 58)
  • Biomarkers (p. 67)
  • Summary and learning objectives (p. 68)
  • Questions (p. 70)
  • Bibliography (p. 71)
  • Chapter 5 Drugs as Toxic Substances (p. 73)
  • Chapter outline (p. 73)
  • Introduction (p. 73)
  • Paracetamol (p. 74)
  • Aspirin (salicylate) (p. 75)
  • Hydralazine (p. 78)
  • Halothane (p. 80)
  • Debrisoquine (p. 81)
  • Thalidomide (p. 82)
  • Drug interactions (p. 83)
  • Altered responsiveness: glucose-6-phosphate dehydrogenase deficiency (p. 84)
  • Summary and learning objectives (p. 85)
  • Questions (p. 86)
  • Bibliography (p. 86)
  • Chapter 6 Industrial Toxicology (p. 89)
  • Chapter outline (p. 89)
  • Industrial chemicals (p. 89)
  • Means of exposure (p. 90)
  • Toxic effects (p. 90)
  • Vinyl chloride (p. 91)
  • Cadmium (p. 92)
  • Aromatic amines (p. 93)
  • Asbestos (p. 94)
  • Legislation (p. 95)
  • Summary and learning objectives (p. 96)
  • Questions (p. 97)
  • Bibliography (p. 98)
  • Chapter 7 Food Additives and Contaminants (p. 99)
  • Chapter outline (p. 99)
  • Introduction (p. 99)
  • Tartrazine (p. 101)
  • Saccharin (p. 102)
  • Food contaminants (p. 103)
  • Summary and learning objectives (p. 106)
  • Questions (p. 106)
  • Bibliography (p. 107)
  • Chapter 8 Pesticides (p. 109)
  • Chapter outline (p. 109)
  • Introduction (p. 109)
  • DDT (p. 111)
  • Organophosphorus compounds (p. 114)
  • Paraquat (p. 116)
  • Fluoroacetate (p. 118)
  • Summary and learning objectives (p. 118)
  • Questions (p. 119)
  • Bibliography (p. 119)
  • Chapter 9 Environmental Pollutants (p. 121)
  • Chapter outline (p. 121)
  • Introduction (p. 121)
  • Air pollution (p. 122)
  • Particulates (p. 125)
  • Acid rain (p. 125)
  • Lead pollution (p. 128)
  • Water pollution (p. 130)
  • Arsenic (p. 131)
  • Food chains (p. 132)
  • Endocrine disruptors (p. 134)
  • Mercury and methylmercury (p. 137)
  • Summary and learning objectives (p. 140)
  • Questions (p. 141)
  • Bibliography (p. 142)
  • Chapter 10 Natural Products (p. 143)
  • Chapter outline (p. 143)
  • Plant toxins (p. 144)
  • Animal toxins (p. 146)
  • Fungal toxins (p. 148)
  • Microbial toxins (p. 148)
  • Summary and learning objectives (p. 149)
  • Questions (p. 150)
  • Bibliography (p. 150)
  • Chapter 11 Household Products (p. 151)
  • Chapter outline (p. 151)
  • Introduction (p. 151)
  • Carbon monoxide (p. 152)
  • Antifreeze: ethylene glycol (p. 154)
  • Cyanide (p. 155)
  • Alcohol (p. 156)
  • Glue sniffing and solvent abuse (p. 157)
  • Antidotes and the treatment of poisoning (p. 157)
  • Summary and learning objectives (p. 159)
  • Questions (p. 160)
  • Bibliography (p. 161)
  • Chapter 12 Toxicity Testing and Risk Assessment (p. 163)
  • Chapter outline (p. 163)
  • Introduction (p. 163)
  • Evaluation of toxicity (p. 164)
  • Acute toxicity tests (p. 167)
  • Sub-acute toxicity tests (p. 168)
  • Chronic toxicity tests (p. 169)
  • Testing in vitro (p. 171)
  • Risk assessment and interpretation of toxicological data (p. 173)
  • Conclusions (p. 179)
  • Summary and learning objectives (p. 180)
  • Questions (p. 181)
  • Bibliography (p. 181)
  • Answers to questions (p. 183)
  • Glossary (p. 197)
  • Index (p. 207)

Author notes provided by Syndetics

John Timbrell is Professor of Biochemical Toxicology in the Pharmacy Department at King's College London