Enhanced descriptions from Syndetics:

Requiring only an introductory background in continuum mechanics, including thermodynamics, fluid mechanics, and solid mechanics, Biofluid Dynamics: Principles and Selected Applications contains review, methodology, and application chapters to build a solid understanding of medical implants and devices. For additional assistance, it includes a glossary of biological terms, many figures illustrating theoretical concepts, numerous solved sample problems, and mathematical appendices. The text is geared toward seniors and first-year graduate students in engineering and physics as well as professionals in medicine and medical implant/device industries. It can be used as a primary selection for a comprehensive course or for a two-course sequence.

The book has two main parts: theory, comprising the first two chapters; and applications, constituting the remainder of the book. Specifically, the author reviews the fundamentals of physical and related biological transport phenomena, such as mass, momentum, and heat transfer in biomedical systems, and highlights complementary topics such as two-phase flow, biomechanics, and fluid-structure interaction. Two appendices summarize needed elements of engineering mathematics and CFD software applications, and these are also found in the fifth chapter. The application part, in form of project analyses, focuses on the cardiovascular system with common arterial diseases, organ systems, targeted drug delivery, and stent-graft implants.

Armed with Biofluid Dynamics, students will be ready to solve basic biofluids-related problems, gain new physical insight, and analyze biofluid dynamics aspects of biomedical systems.

Table of contents provided by Syndetics

• Preface (p. xiii)
• Glossary (p. xvii)
• I Elements of Continuum Mechanics (p. 1)
• 1.1 Biological Transport Processes (p. 2)
• 1.1.1 Micro-to Macro-scale Systems (p. 2)
• 1.1.2 Solute Transport (p. 7)
• 1.2 Basic Momentum, Heat, and Mass Transfer Concepts (p. 13)
• 1.2.1 Continuum Mechanics Axioms (p. 18)
• 1.2.2 Flow Field Descriptions (p. 19)
• 1.2.2.1 Lagrangian Description (p. 20)
• 1.2.2.2 Eulerian Description (p. 21)
• 1.2.3 Derivation Approaches (p. 22)
• 1.3 Conservation Laws (p. 24)
• 1.3.1 Mass Conservation (p. 26)
• 1.3.2 Momentum Conservation (Integral Approach) (p. 27)
• 1.3.2.1 Stress Tensors and Stress Vectors (p. 30)
• 1.3.2.2 Equation of Motion and its Special Cases (p. 34)
• 1.3.2.3 Force Balance Derivation (p. 36)
• 1.3.3 Energy Conservation (p. 42)
• 1.3.3.1 Heat and Mass Transfer Equations (p. 43)
• 1.3.3.2 Basic Heat and Mass Transfer Applications (p. 44)
• 1.3.4 Turbulent Flow Equations (p. 49)
• 1.3.4.1 Aspects of Turbulence (p. 49)
• 1.3.4.2 Turbulence Scales (p. 54)
• 1.3.4.3 Summary of Turbulence Modeling (p. 55)
• 1.3.5 Solution Techniques (p. 64)
• 1.3.5.1 Solution Methods for Differential Equations (p. 67)
• 1.3.5.2 Solution Procedures for the Navier-Stokes Equations (p. 67)
• 1.3.5.3 Similarity Theory (p. 71)
• 1.3.5.4 Integral Methods (p. 72)
• 1.3.5.5 Dimensional Analysis and Scaling (p. 76)
• 1.4 Two-Phase Flows (p. 78)
• 1.4.1 Modeling Approaches (p. 79)
• 1.4.1.1 Definitions (p. 81)
• 1.4.1.2 Phase Coupling (p. 83)
• 1.4.2 Mixture Models (p. 88)
• 1.4.2.1 Homogeneous and Non-Newtonian Flow Models (p. 88)
• 1.4.2.2 Drift-Flux Model (p. 98)
• 1.4.3 Separated Flow Models (p. 99)
• 1.4.3.1 Particle Trajectory Models (p. 99)
• 1.4.3.2 Species Mass Transfer (p. 108)
• 1.4.4 Porous Media Flow (p. 109)
• 1.5 Biomechanics Review (p. 120)
• 1.5.1 Introduction (p. 120)
• 1.5.2 Principal Stresses (p. 120)
• 1.5.3 Equilibrium Conditions (p. 126)
• 1.5.4 Deformation Analysis and Stress-Strain Relationships (p. 127)
• 1.5.5 Simplifications (p. 131)
• 1.6 Summary and Outlook (p. 137)
• 1.7 Homework Assignments (p. 139)
• References (p. 155)
• II Biofluid Dynamics Concepts (p. 161)
• 2.1 Transport Phenomena (p. 162)
• 2.1.1 Biofluid-compartment Models (p. 163)
• 2.1.2 Tissue Heat and Mass Transfer (p. 173)
• 2.1.3 Joint Lubrication (p. 186)
• 2.1.4 Cell Transport and Microvascular Beds (p. 192)
• 2.2 The Cardiovascular System (p. 197)
• 2.2.1 Cardiovascular Transport Dynamics (p. 197)
• 2.2.2 The Heart (p. 199)
• 2.2.3 The Blood Vessels (p. 209)
• 2.3 Homework Problems (p. 232)
• References (p. 237)
• III Analyses of Arterial Diseases (p. 241)
• 3.1 Vessel Occlusions (p. 241)
• 3.1.1 Atherosclerotic Plaque Formation (p. 242)
• 3.1.1.1 A Particle-Hemodynamics Model (p. 244)
• 3.1.1.2 A Pathway Model for Atherogenesis (p. 244)
• 3.1.2 Intimal Hyperplasia Development (p. 245)
• 3.1.3 Thrombogenesis (p. 246)
• 3.1.4 Particle-Hemodynamics (p. 247)
• 3.1.4.1 Equations of Particle Motion (p. 251)
• 3.1.4.2 Near-Wall Forces (p. 254)
• 3.1.4.3 Hemodynamic Wall Parameters (p. 257)
• 3.1.5 Treatment Option: Femoral End-to-Side Graft Bypass (p. 265)
• 3.1.5.1 Computational Fluid-Particle Dynamics Solution (p. 266)
• 3.1.5.2 Model Validation (p. 271)
• 3.1.5.3 Results for a Distal End-to-Side Femoral Bypass (p. 272)
• 3.1.5.4 Novel System Design and Discussion (p. 276)
• 3.2 Aneurysms (p. 278)
• 3.2.1 Aortic Aneurysms (p. 279)
• 3.2.1.1 Mechanisms of AAA Development (p. 280)
• 3.2.1.2 AAA-Wall Stress and Rupture (p. 282)
• 3.2.2 Treatment Option: Stent-graft Implants (p. 283)
• 3.2.3 Stented AAA-model Analysis (p. 284)
• 3.2.3.1 Basic Structure Equations (p. 287)
• 3.2.3.2 Numerical Method (p. 287)
• 3.2.3.3 Model Validations (p. 289)
• 3.2.3.4 Results and Discussion (p. 290)
• 3.2.3.5 Conclusions (p. 295)
• 3.3 Examples of Computerized Disease Management (p. 296)
• 3.3.1 Introduction (p. 296)
• 3.3.2 Image File Conversion Steps (p. 297)
• 3.3.3 A Stenosed Artery Model for Surgical Bypass Planning (p. 303)
• 3.3.4 AAA-Rupture Prediction (p. 306)
• 3.4 Homework Problems (p. 311)
• References (p. 313)
• IV Biofluid Mechanics of Organ Systems (p. 321)
• 4.1 The Lungs (p. 322)
• 4.1.1 Respiratory Tract Geometry (p. 328)
• 4.1.2 Pulmonary Disorders and Treatment Options (p. 330)
• 4.2 The Kidneys (p. 339)
• 4.2.1 Kidney Structure and Functions (p. 340)
• 4.2.2 Fluid Flow and Mass Transfer in an Artificial Kidney Model (p. 342)
• 4.3 The Liver (p. 349)
• 4.3.1 Liver Structure and Functions (p. 351)
• 4.3.2 Fluid Flow and Mass Transfer in a Liver Model (p. 351)
• 4.4 Homework Problems (p. 358)
• References (p. 361)
• V Case Studies in Biofluid Dynamics (p. 363)
• 5.1 Prerequisites for Modeling and Simulating (p. 364)
• 5.1.1 Problem Recognition and System Conceptualization (p. 366)
• 5.1.2 Types of Models and Modeling Approaches (p. 367)
• 5.1.3 Mathematical Representation and System Simulation (p. 371)
• 5.2 Nanodrug Delivery in Microchannels (p. 376)
• 5.2.1 Flow in Microchannels (p. 377)
• 5.2.1.1 Numerical Solution Techniques (p. 378)
• 5.2.1.2 Microchannel Flow Effects (p. 383)
• 5.2.2 Controlled Nanodrug Delivery in Microchannels (p. 392)
• 5.3 Particle Deposition and Targeting in Human Lung Airways (p. 397)
• 5.3.1 Nanoparticle and Microparticle Depositions in a Human Upper Airway Model (p. 399)
• 5.3.2 Modeling Approach and Results (p. 399)
• 5.3.2.1 Numerical Method (p. 404)
• 5.3.2.2 Model Validations (p. 405)
• 5.3.2.3 Results and Discussion (p. 407)
• 5.3.2.4 Conclusions (p. 418)
• 5.3.3 Micro-drug Aerosol Targeting in Lung Airways (p. 419)
• 5.4 Fluid-Structure Interactions in Stented Aneurysms (p. 422)
• 5.4.1 Aneurysms and Their Possible Repairs (p. 422)
• 5.4.2 A Stented Abdominal Aortic Aneurysm Model (p. 426)
• 5.4.2.1 Introduction (p. 426)
• 5.4.2.2 Theory (p. 428)
• 5.4.2.3 Results (p. 434)
• 5.4.2.4 Discussion (p. 441)
• 5.5 Project Assignments (p. 443)
• References (p. 445)
• Appendices (p. 451)
• A Review of Tensor Calculus, Differential Operations, Integral Transformations, and ODE Solutions (p. 452)
• B Single-Phase Field Equations (p. 468)
• C Suitable CFD Solvers (p. 470)
• D Physical Properties (p. 475)
• References (p. 478)
• Index (p. 479)

Author notes provided by Syndetics