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Process analytical technology : spectroscopic tools and implementation strategies for the chemical and pharmaceutical industries / edited by Katherine A. Bakeev.

Contributor(s): Bakeev, Katherine A.
Material type: materialTypeLabelBookPublisher: Chichester, West Sussex : Wiley, 2010Copyright date: ©2010Edition: Second edition.Description: xxiv, 557 pages : ill. ; 26 cm. + hbk.Content type: text Media type: unmediated Carrier type: volumeISBN: 9780470722077 ; 047072207X .Subject(s): Chemistry, Technical | Chemistry, Analytic -- Technological innovations | Chemistry, Analytic -- Technique | Spectrum analysis | Pharmaceutical chemistryDDC classification: 660.2 | 660.2 PRO
Contents:
Machine generated contents note: Chapter 1 -- Overview of Process Analysis and PAT -- Jason E. Dickens -- 1.1 Introduction -- 1.2 Execution of Process Analysis Projects -- 1.3 Process Instrumentation -- 1.4 Conclusions -- 1.5 Glossy of Acronyms and Terms -- 1.6 References -- Chapter 2 -- Implementation of Process Analytical Technologies -- Robert Guenard and Gert Thurau -- 2.1 Introduction to implementation of process analytical technologies (PAT) in the industrial setting -- 2.2 Generalized process analytics work process -- 2.3 Considerations for PAT implementation in the pharmaceutical industry -- 2.4 Conclusions -- 2.5 References -- Chapter 3 -- Process Sampling: Theory of Sampling - the missing link in Process Analytical Technologies (PAT) -- Kim H. Esbensen and Peter Paasch-Mortensen -- 3.1 Introduction -- 3.2 Theory of Sampling TOS - introduction -- 3.3 Mass reduction as a specific sampling procedure -- 3.4 Fundamental Sampling Principle (FSP) -- 3.5 Sampling - a very practical issue -- 3.6 Reactors vessels - identical process sampling issues -- 3.7 Heterogeneity characterisaton of 1-d lots: variography -- 3.8 Data Quality - new insight from THE TOS -- 3.9 Validation in chemometrics AND PAT -- 3.10 Summary -- References -- Chapter 4 -- UV-visible spectroscopy for On-Line Analysis -- Marcel A. Liauw, Lewis C. Baylor and Patrick E. O\'Rourke -- 4.1 Introduction -- 4.2 Theory -- 4.3 Instrumentation -- 4.4 Sample interface -- 4.5 Implementation -- 4.6 Applications -- 4.7 Detailed application notes -- 4.8 Conclusion -- References -- Chapter 5 -- Near-infrared Spectroscopy for Process Analytical Technology : Theory, Technology and Implementation -- Michael B. Simpson -- 5.1 Introduction -- 5.2 Theory of near-infrared spectroscopy -- 5.3 Analyser technologies in the near-infrared -- 5.4 The sampling interface -- 5.5 Practical examples of near-infrared analytical applications -- 5.6 Conclusion -- References --
Chapter 6 -- Infrared Spectroscopy for Process Analytical Applications -- John P. Coates -- 6.1 Introduction -- 6.2 Practical aspects of IR Spectroscopy -- 6.3 Instrumentation Design and Technology -- 6.4 Process IR Instrumentation -- 6.5 Applications of Process IR Analyzers -- 6.6 Process IR Analyzers: A Review -- 6.7 Trends and Directions -- Abbreviations and Acronyms -- References -- Chapter 7 -- Raman Spectroscopy -- Dr. Nancy L. Jestel -- 7.1 Attractive features of Raman spectroscopy -- 7.2 Potential issues with Raman spectroscopy -- 7.3 Fundamentals of Raman spectroscopy -- 7.4 Raman instrumentation -- 7.5 Quantitative Raman -- 7.6 Applications -- 7.7 Current state of process Raman spectroscopy -- 7.8 References -- Chapter 8 -- Near-Infrared Chemical Imaging for Product and Process Understanding -- E. Neil Lewis, Joseph W. Schoppelrei, Lisa Makein, Linda H. Kidder and Eunah Lee -- 8.1 The PAT initiative -- 8.2 The role of near-infrared chemical imaging (NIR-CI) in the pharmaceutical industry -- 8.3 Evolution of NIR imaging instrumentation -- 8.4 Chemical imaging principles -- 8.5 PAT applications -- 8.6 Processing case study one: estimating \'abundance\' of sample components -- 8.7 Processing case study two: determining blend homogeneity through statistical analysis -- 8.8 Final thoughts -- Acknowledgements -- Chapter 9: -- Acoustic chemometric monitoring of industrial production processes -- Maths Halstensen & Kim H. Esbensen -- 9.1 What is acoustic chemometrics? -- 9.2 How acoustic chemometrics works -- 9.3 Industrial production process monitoring -- 9.4 Available on-line acoustic chemometric equipment -- 9.5 Discussion -- 9.6 Conclusions -- 9.7 References -- Chapter 10 -- Process NMR Spectroscopy: Technology and On-line Applications -- John C. Edwards, Ph.D. and Paul J. Giammatteo, Ph.D. -- 10.1 Introduction -- 10.2NMR Spectroscopy Overview -- 10.3 Process NMR Instrumentation -- 10.4 Postprocessing methodologies for NMR data -- 10.5 Advantages and limitations of NMR as a process analytical technology -- 10.6 On-line and at-line applications -- 10.7 Current Development and Applications -- 10.8 Conclusions -- References --
Chapter 11 -- Fluorescent Sensing and Process Analytical Applications -- Jason E. Dickens -- 11.1 Introduction -- 11.2 Luminescence fundamentals -- 11.3 LIF sensing fundamentals -- 11.4 LIF sensing instrumentation -- 11.5 Luminescent detection risks -- 11.6 Process analytical technology applications -- 11.7 Conclusions -- References -- Chapter 12 -- Chemometrics in Process Analytical Technology (PAT) -- Charles E. Miller -- 12.1 Introduction -- 12.2 Foundations of Chemometrics -- 12.3 Chemometric Methods in PAT -- 12.4 Overfitting and Model Validation -- 12.5 Outliers -- 12.6 Calibration Strategies in PAT -- 12.7 Sample and Variable Selection in Chemometrics -- 12.8 Troubleshooting/Improving an Existing Method -- 12.9 Calibration Transfer and Instrument Standardization -- 12.10 Chemometric Model Deployment Issues in PAT -- 12.11 People Issues -- 12.12 The Final Word -- Chapter 13 -- On-line PAT Applications of Spectroscopy in the Pharmaceutical Industry -- Brandye Smith-Goettler -- 13.1 Background -- 13.2 Reaction monitoring -- 13.3 Crystallization -- 13.4 API drying -- 13.5 Nanomilling -- 13.6 Hot-melt extrusion -- 13.7 Granulation -- 13.8 Powder blending -- 13.9 Compression -- 13.10 Coating -- 13.11 Biologics -- 13.12 Cleaning validation -- 13.13 Conclusions -- References -- Chapter 14 -- NIR spectroscopy in pharmaceutical analysis: Off-line and At-line PAT Applications -- Prof. Marcelo Blanco Romi;a -- 14.1 Introduction -- 14.2 Foundation of qualitative method development -- 14.3 Foundation of quantitative method development -- 14.4 Method validation -- 14.5 Calibration transfer -- 14.6 Pharmaceutical applications -- 14.7 Conclusions -- Chapter 15 -- Near-Infrared Spectroscopy (NIR) as a PAT tool in the Chemical Industry: Added value and implementation challenges -- Ann M. Brearley and Susan J. Foulk -- 15.1 Introduction -- 15.2 Successful process analyzer implementation -- 15.3 Example applications -- Chapter 16 -- Future trends for PAT for increased process understanding and growing applications in biomanufacturing -- Katherine A. Bakeev and Jose C. Menezes -- 16.1 Introduction -- 16.2 Regulatory Guidance and its Impact on PAT -- 16.3 Going Beyond Process Analyzers Towards Solutions -- 16.4 Emerging Application Areas of PAT -- 16.5 New and Emerging Sensor and Control Technologies -- 16.6 Advances in sampling: NeSSI[trademark symbol] -- 16.7 Challenges Ahead -- 16.8 Conclusion -- References.
Summary: Process Analytical Technology 2nd ed. explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the spectroscopist. This second edition cover all the topics that are in the first edition, with additional chapters on process sampling, NMR spectroscopy and fluorescence spectroscopy (tbc). Other chapters cover the key spectroscopic tools, their applications in the chemical and pharmaceutical industries and basic chemometrics--Provided by publisher.
Holdings
Item type Current library Call number Copy number Status Notes Date due Barcode
General lending MTU Bishopstown Library Lending 660.2 (Browse shelf(Opens below)) 1 Checked out 20/10/2026 00169211
2 hour loan MTU Kerry North Campus Library Desk Loan 660.2 PRO (Browse shelf(Opens below)) Available MTU Kerry Module FACL81004 - Essential reading. 38888000956304
Total holds: 0

Enhanced descriptions from Syndetics:

Process Analytical Technology explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added.

Coverage includes:

Implementation of Process Analytical Technologies UV-Visible Spectroscopy for On-line Analysis Infrared Spectroscopy for Process Analytical Applications Process Raman Spectroscopy Process NMR Spectrscopy: Technology and On-line Applications Fluorescent Sensing and Process Analytical Applications Chemometrics in Process Analytical Technology (PAT) On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing NIR Chemical Imaging

This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT.

It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT.

Review from the First Edition

"The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology."-- Current Engineering Practice

Includes bibliographical references and index.

Machine generated contents note: Chapter 1 -- Overview of Process Analysis and PAT -- Jason E. Dickens -- 1.1 Introduction -- 1.2 Execution of Process Analysis Projects -- 1.3 Process Instrumentation -- 1.4 Conclusions -- 1.5 Glossy of Acronyms and Terms -- 1.6 References -- Chapter 2 -- Implementation of Process Analytical Technologies -- Robert Guenard and Gert Thurau -- 2.1 Introduction to implementation of process analytical technologies (PAT) in the industrial setting -- 2.2 Generalized process analytics work process -- 2.3 Considerations for PAT implementation in the pharmaceutical industry -- 2.4 Conclusions -- 2.5 References -- Chapter 3 -- Process Sampling: Theory of Sampling - the missing link in Process Analytical Technologies (PAT) -- Kim H. Esbensen and Peter Paasch-Mortensen -- 3.1 Introduction -- 3.2 Theory of Sampling TOS - introduction -- 3.3 Mass reduction as a specific sampling procedure -- 3.4 Fundamental Sampling Principle (FSP) -- 3.5 Sampling - a very practical issue -- 3.6 Reactors vessels - identical process sampling issues -- 3.7 Heterogeneity characterisaton of 1-d lots: variography -- 3.8 Data Quality - new insight from THE TOS -- 3.9 Validation in chemometrics AND PAT -- 3.10 Summary -- References -- Chapter 4 -- UV-visible spectroscopy for On-Line Analysis -- Marcel A. Liauw, Lewis C. Baylor and Patrick E. O\'Rourke -- 4.1 Introduction -- 4.2 Theory -- 4.3 Instrumentation -- 4.4 Sample interface -- 4.5 Implementation -- 4.6 Applications -- 4.7 Detailed application notes -- 4.8 Conclusion -- References -- Chapter 5 -- Near-infrared Spectroscopy for Process Analytical Technology : Theory, Technology and Implementation -- Michael B. Simpson -- 5.1 Introduction -- 5.2 Theory of near-infrared spectroscopy -- 5.3 Analyser technologies in the near-infrared -- 5.4 The sampling interface -- 5.5 Practical examples of near-infrared analytical applications -- 5.6 Conclusion -- References --

Chapter 6 -- Infrared Spectroscopy for Process Analytical Applications -- John P. Coates -- 6.1 Introduction -- 6.2 Practical aspects of IR Spectroscopy -- 6.3 Instrumentation Design and Technology -- 6.4 Process IR Instrumentation -- 6.5 Applications of Process IR Analyzers -- 6.6 Process IR Analyzers: A Review -- 6.7 Trends and Directions -- Abbreviations and Acronyms -- References -- Chapter 7 -- Raman Spectroscopy -- Dr. Nancy L. Jestel -- 7.1 Attractive features of Raman spectroscopy -- 7.2 Potential issues with Raman spectroscopy -- 7.3 Fundamentals of Raman spectroscopy -- 7.4 Raman instrumentation -- 7.5 Quantitative Raman -- 7.6 Applications -- 7.7 Current state of process Raman spectroscopy -- 7.8 References -- Chapter 8 -- Near-Infrared Chemical Imaging for Product and Process Understanding -- E. Neil Lewis, Joseph W. Schoppelrei, Lisa Makein, Linda H. Kidder and Eunah Lee -- 8.1 The PAT initiative -- 8.2 The role of near-infrared chemical imaging (NIR-CI) in the pharmaceutical industry -- 8.3 Evolution of NIR imaging instrumentation -- 8.4 Chemical imaging principles -- 8.5 PAT applications -- 8.6 Processing case study one: estimating \'abundance\' of sample components -- 8.7 Processing case study two: determining blend homogeneity through statistical analysis -- 8.8 Final thoughts -- Acknowledgements -- Chapter 9: -- Acoustic chemometric monitoring of industrial production processes -- Maths Halstensen & Kim H. Esbensen -- 9.1 What is acoustic chemometrics? -- 9.2 How acoustic chemometrics works -- 9.3 Industrial production process monitoring -- 9.4 Available on-line acoustic chemometric equipment -- 9.5 Discussion -- 9.6 Conclusions -- 9.7 References -- Chapter 10 -- Process NMR Spectroscopy: Technology and On-line Applications -- John C. Edwards, Ph.D. and Paul J. Giammatteo, Ph.D. -- 10.1 Introduction -- 10.2NMR Spectroscopy Overview -- 10.3 Process NMR Instrumentation -- 10.4 Postprocessing methodologies for NMR data -- 10.5 Advantages and limitations of NMR as a process analytical technology -- 10.6 On-line and at-line applications -- 10.7 Current Development and Applications -- 10.8 Conclusions -- References --

Chapter 11 -- Fluorescent Sensing and Process Analytical Applications -- Jason E. Dickens -- 11.1 Introduction -- 11.2 Luminescence fundamentals -- 11.3 LIF sensing fundamentals -- 11.4 LIF sensing instrumentation -- 11.5 Luminescent detection risks -- 11.6 Process analytical technology applications -- 11.7 Conclusions -- References -- Chapter 12 -- Chemometrics in Process Analytical Technology (PAT) -- Charles E. Miller -- 12.1 Introduction -- 12.2 Foundations of Chemometrics -- 12.3 Chemometric Methods in PAT -- 12.4 Overfitting and Model Validation -- 12.5 Outliers -- 12.6 Calibration Strategies in PAT -- 12.7 Sample and Variable Selection in Chemometrics -- 12.8 Troubleshooting/Improving an Existing Method -- 12.9 Calibration Transfer and Instrument Standardization -- 12.10 Chemometric Model Deployment Issues in PAT -- 12.11 People Issues -- 12.12 The Final Word -- Chapter 13 -- On-line PAT Applications of Spectroscopy in the Pharmaceutical Industry -- Brandye Smith-Goettler -- 13.1 Background -- 13.2 Reaction monitoring -- 13.3 Crystallization -- 13.4 API drying -- 13.5 Nanomilling -- 13.6 Hot-melt extrusion -- 13.7 Granulation -- 13.8 Powder blending -- 13.9 Compression -- 13.10 Coating -- 13.11 Biologics -- 13.12 Cleaning validation -- 13.13 Conclusions -- References -- Chapter 14 -- NIR spectroscopy in pharmaceutical analysis: Off-line and At-line PAT Applications -- Prof. Marcelo Blanco Romi;a -- 14.1 Introduction -- 14.2 Foundation of qualitative method development -- 14.3 Foundation of quantitative method development -- 14.4 Method validation -- 14.5 Calibration transfer -- 14.6 Pharmaceutical applications -- 14.7 Conclusions -- Chapter 15 -- Near-Infrared Spectroscopy (NIR) as a PAT tool in the Chemical Industry: Added value and implementation challenges -- Ann M. Brearley and Susan J. Foulk -- 15.1 Introduction -- 15.2 Successful process analyzer implementation -- 15.3 Example applications -- Chapter 16 -- Future trends for PAT for increased process understanding and growing applications in biomanufacturing -- Katherine A. Bakeev and Jose C. Menezes -- 16.1 Introduction -- 16.2 Regulatory Guidance and its Impact on PAT -- 16.3 Going Beyond Process Analyzers Towards Solutions -- 16.4 Emerging Application Areas of PAT -- 16.5 New and Emerging Sensor and Control Technologies -- 16.6 Advances in sampling: NeSSI[trademark symbol] -- 16.7 Challenges Ahead -- 16.8 Conclusion -- References.

Process Analytical Technology 2nd ed. explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the spectroscopist. This second edition cover all the topics that are in the first edition, with additional chapters on process sampling, NMR spectroscopy and fluorescence spectroscopy (tbc). Other chapters cover the key spectroscopic tools, their applications in the chemical and pharmaceutical industries and basic chemometrics--Provided by publisher.

CIT Module CHEP 7003 - Core reading.

MTU Kerry Module FACL81004 - Essential reading.

Table of contents provided by Syndetics

  • Preface to the Second Edition
  • List of Contributors
  • List of Abbreviations
  • 1 Overview of Process Analysis and PAT
  • 1.1 Introduction
  • 1.2 Execution of Process Analysis Projects
  • 1.3 Process Instrumentation
  • 1.4 Conclusions
  • 1.5 Glossary of Acronyms and Terms
  • 2 Implementation of Process Analytical Technologies
  • 2.1 Introduction to Implementation of Process Analytical Technologies (PAT) in the Industrial Setting
  • 2.2 Generalized Process Analytics Work Process
  • 2.3 Considerations for PAT Implementation in the Pharmaceutical Industry
  • 2.4 Conclusions
  • 3 Process Sampling: Theory of Sampling - the Missing Link in Process Analytical Technologies (PAT)
  • 3.1 Introduction
  • 3.2 Theory of Sampling - Introduction
  • 3.3 Mass Reduction as a Specifi c Sampling Procedure
  • 3.4 Fundamental Sampling Principle
  • 3.5 Sampling - a Very Practical Issue
  • .6 Reactors and Vessels - Identical Process Sampling Issues
  • 3.7 Heterogeneity Characterization of 1-D lots: Variography
  • 3.8 Data Quality - New Insight from the TOS
  • 3.9 Validation in Chemometrics and PAT
  • 3.10 Summary
  • 4 UV-visible Spectroscopy for On-line Analysis
  • 4.1 Introduction
  • 4.2 Theory
  • 4.3 Instrumentation
  • 4.4 Sample Interface
  • 4.5 Implementation
  • 4.6 Applications
  • 4.7 Detailed Application Notes
  • 4.8 Conclusion
  • 5 Near-infrared Spectroscopy for Process Analytical Technology: Theory, Technology and Implementation
  • 5.1 Introduction
  • 5.2 Theory of Near-infrared Spectroscopy
  • 5.3 Analyser Technologies in the Near-infrared
  • 5.4 The Sampling Interface
  • 5.5 Practical Examples of Near-infrared Analytical Applications
  • 5.6 Conclusion
  • 6 Infrared Spectroscopy for Process Analytical Applications
  • 6.1 Introduction
  • 6.2 Practical Aspects of IR Spectroscopy
  • 6.3 Instrumentation Design and Technology
  • 6.4 Process IR Instrumentation
  • 6.5 Applications of Process IR Analyzers
  • 6.6 Process IR Analyzers: a Review
  • 6.7 Trends and Directions
  • 7 Raman Spectroscopy
  • 7.1 Attractive Features of Raman Spectroscopy
  • 7.2 Potential Issues with Raman Spectroscopy
  • 7.3 Fundamentals of Raman Spectroscopy
  • 7.4 Raman Instrumentation
  • 7.5 Quantitative Raman
  • 7.6 Applications
  • 7.7 Current State of Process Raman Spectroscopy
  • 8 Near-infrared Chemical Imaging for Product and Process Understanding
  • 8.1 The PAT Initiative
  • 8.2 The Role of Near-infrared Chemical Imaging (NIR-CI) in the Pharmaceutical Industry
  • 8.3 Evolution of NIR Imaging Instrumentation
  • 8.4 Chemical Imaging Principles
  • 8.5 PAT Applications
  • 8.6 Processing Case Study: Estimating 'Abundance' of Sample Components
  • 8.7 Processing Case Study: Determining Blend Homogeneity Through Statistical Analysis
  • 8.8 Final Thoughts
  • 9 Acoustic Chemometric Monitoring of Industrial Production Processes
  • 9.1 What is Acoustic Chemometrics?
  • 9.2 How Acoustic Chemometrics Works
  • 9.3 Industrial Production Process Monitoring
  • 9.4 Available On-line Acoustic Chemometric Equipment
  • 9.5 Discussion
  • 9.6 Conclusions
  • 10 Process NMR Spectroscopy: Technology and On-line Applications
  • 10.1 Introduction
  • 10.2 NMR Spectroscopy Overview
  • 10.3 Process NMR Instrumentation
  • 10.4 Postprocessing Methodologies for NMR Data
  • 10.5 Advantages and Limitations of NMR as a Process Analytical Technology
  • 10.6 On-line and At-line Applications
  • 10.7 Current Development and Applications
  • 10.8 Conclusions
  • 11 Fluorescent Sensing and Process Analytical Applications
  • 11.1 Introduction
  • 11.2 Luminescence Fundamentals
  • 11.3 LIF Sensing Fundamentals
  • 11.4 LIF Sensing Instrumentation
  • 11.5 Luminescent Detection Risks
  • 11.6 Process Analytical Technology Applications
  • 11.7 Conclusions
  • 12 Chemometrics in Process Analytical Technology (PAT)
  • 12.1 Introduction
  • 12.2 Foundations of Chemometrics
  • 12.3 Chemometric Methods in PAT
  • 12.4 Overfi tting and Model Validation
  • 12.5 Outliers
  • 12.6 Calibration Strategies in PAT
  • 12.7 Sample and Variable Selection in Chemometrics
  • 12.8 Troubleshooting/Improving an Existing Method
  • 12.9 Calibration Transfer and Instrument Standardization
  • 12.10 Chemometric Model Deployment Issues in PAT
  • 12.11 People Issues
  • 12.12 The Final Word
  • 13 On-line PAT Applications of Spectroscopy in the Pharmaceutical Industry
  • 13.1 Background
  • 13.2 Reaction Monitoring
  • 13.3 Crystallization
  • 13.4 API Drying
  • 13.5 Nanomilling
  • 13.6 Hot-melt Extrusion
  • 13.7 Granulation
  • 13.8 Powder Blending
  • 13.9 Compression
  • 13.10 Coating
  • 13.11 Biologics
  • 13.12 Cleaning Validation
  • 13.13 Conclusions
  • 14 NIR spectroscopy in Pharmaceutical Analysis: Off-line and At-line PAT Applications
  • 14.1 Introduction
  • 14.2 Foundation of Qualitative Method Development
  • 14.3 Foundation of Quantitative Method Development
  • 14.4 Method Validation
  • 14.5 Calibration Transfer
  • 14.6 Pharmaceutical Applications
  • 14.7 Conclusions
  • 15 Near-infrared Spectroscopy (NIR) as a PAT Tool in the Chemical Industry: Added Value and Implementation Challenges
  • 15.1 Introduction
  • 15.2 Successful Process Analyzer Implementation
  • 15.3 Example Applications
  • 16 Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing
  • 16.1 Introduction
  • 16.2 Regulatory Guidance and its Impact on PAT
  • 16.3 Going Beyond Process Analyzers Towards Solutions
  • 16.4 Emerging Application Areas of PAT
  • 16.5 New and Emerging Sensor and Control Technologies
  • 16.6 Advances in Sampling: NeSSI
  • 16.7 Challenges Ahead
  • 16.8 Conclusion
  • References
  • Index

Author notes provided by Syndetics

Katherine A. Bakeev is Principal Scientist with GlaxoSmithKline in King of Prussia, PA where she works in the Process Analytics and Chemometrics group supporting chemical development. She has twelve years of industrial experience including work in process analytical chemistry with ISP, and as a product specialist for Foss NIRSystems. She holds a PhD in Polymer Science and Engineering from the University of Massachusetts in Amherst, and a Masters in Technology Management from Stevens Institute of Technology. She has given numerous presentations on the use of near-infrared spectroscopy (NIR), and in 2007 received the Coblentz Society Craver Award for her work in NIR and chemometrics.