MTU Library Catalogue

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Textbook of drug design and discovery / [edited by] Povl Krogsgaard-Larsen, Tommy Liljefors and Ulf Madsen.

Contributor(s): Krogsgaard-Larsen, Povl | Liljefors, Tommy | Madsen, Ulf.
Material type: materialTypeLabelBookPublisher: London ; New York : Taylor & Francis, 2002Edition: 3rd ed.Description: xviii, 572 p.ISBN: 0415282888.Subject(s): Drugs -- DesignDDC classification: 615.19
Contents:
Drug design and discovery: an overview / Lester A. Mitscher -- Role of molecular recognition in drug design / Peter Andrews and Michael Dooley -- Stereochemistry in drug design / Ian J. Kennedy and David E. Jane -- Computer-aided development and use of three-dimensional pharmacophore models / Tommy Liljefors and Ingrid Pettersson -- Quantitative structure-activity relationships and experimental design / Ulf Norinder and Thomas Hogberg -- Receptors: structure, function and pharmacology / Hans Brauner-Osborne -- Ion channels: structure, function and pharmacology / David J. Triggle -- Radiotracers: synthesis and use in imaging / Christer Halldin and Thomas Hogberg -- Excitatory and inhibitory amino acid receptor ligands / Ulf Madsen and Bente Frolund -- Acetylcholine and histamine receptors and receptor ligands: medicinal chemistry and therapeutic aspects / Povl Krogsgaard-Larsen and Karla Frydenvang -- Dopamine and serotonin receptor and transporter ligands / Klaus P. Bogeso and Benny Bang-Andersen -- Enzymes and enzyme inhibitors / Robert A. Copeland and Paul S. Anderson -- Metals in medicine: inorganic medicinal chemistry / Ole Farver -- Design and application of prodrugs / Claus S. Larsen and Jesper Ostergaard -- Peptides and peptidomimetics / Kristina Luthman and Uli Hacksell -- Classical antiviral agents and design of new antiviral agents / Piet Herdewijn and Erik De Clercq -- Anticancer agents / Ingrid Kjoller Larsen and Jette Sandholm Kastrup.

Enhanced descriptions from Syndetics:

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine.

The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Includes bibliographical references and index.

Drug design and discovery: an overview / Lester A. Mitscher -- Role of molecular recognition in drug design / Peter Andrews and Michael Dooley -- Stereochemistry in drug design / Ian J. Kennedy and David E. Jane -- Computer-aided development and use of three-dimensional pharmacophore models / Tommy Liljefors and Ingrid Pettersson -- Quantitative structure-activity relationships and experimental design / Ulf Norinder and Thomas Hogberg -- Receptors: structure, function and pharmacology / Hans Brauner-Osborne -- Ion channels: structure, function and pharmacology / David J. Triggle -- Radiotracers: synthesis and use in imaging / Christer Halldin and Thomas Hogberg -- Excitatory and inhibitory amino acid receptor ligands / Ulf Madsen and Bente Frolund -- Acetylcholine and histamine receptors and receptor ligands: medicinal chemistry and therapeutic aspects / Povl Krogsgaard-Larsen and Karla Frydenvang -- Dopamine and serotonin receptor and transporter ligands / Klaus P. Bogeso and Benny Bang-Andersen -- Enzymes and enzyme inhibitors / Robert A. Copeland and Paul S. Anderson -- Metals in medicine: inorganic medicinal chemistry / Ole Farver -- Design and application of prodrugs / Claus S. Larsen and Jesper Ostergaard -- Peptides and peptidomimetics / Kristina Luthman and Uli Hacksell -- Classical antiviral agents and design of new antiviral agents / Piet Herdewijn and Erik De Clercq -- Anticancer agents / Ingrid Kjoller Larsen and Jette Sandholm Kastrup.

Table of contents provided by Syndetics

  • List of contributors (p. xiv)
  • Preface (p. xvii)
  • 1 Drug design and discovery: an overview (p. 1)
  • 2 Roke of noodecular recognition in drug design (p. 35)
  • 3 Stereochemistry in drug design (p. 54)
  • 4 Computer-aided development and use of three-dimensional pharmacophore models (p. 86)
  • 5 Quantitative structure-activity relationships and experimental design (p. 117)
  • 6 Receptors: structure, function and pharmacology (p. 156)
  • 7 Ion channels: structure, function and pharmacology (p. 173)
  • 8 Radiotracers: synthesis and use in imaging (p. 205)
  • 9 Excitatory and inhibitory amino acid receptor ligands (p. 232)
  • 10 Acetylcholine and histamine receptors and receptor ligands: medicinal chemistry and therapeutic aspects (p. 272)
  • 11 Dopamine and serotonin receptor and transporter ligands (p. 299)
  • 12 Enzymes and enzyme inhibitors (p. 328)
  • 13 Metals in medicine: inorganic medicinal chemistry (p. 364)
  • 14 Design and application of prodrugs (p. 410)
  • 15 Peptides and peptidomimetics (p. 459)
  • 16 Classical antiviral agents and design of new antiviral agents (p. 486)
  • 17 Anticancer agents (p. 511)
  • Index (p. 559)